Landscape of Dysregulated Placental RNA Editing Associated With Preeclampsia
Landscape of Dysregulated Placental RNA Editing Associated With Preeclampsia
复制标题
与先兆子痫相关的胎盘 RNA 编辑失调的情况
DOI：
10.1161/hypertensionaha.120.14756
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发表时间：
2020-01
期刊：
影响因子：
8.3
通讯作者：
Yang Xinping
中科院分区：
文献类型：
--
作者：
Yang Xiaoxue;Yang Jing;Liang Xiaozhen;Chen Qian;Jiang Sijia;Liu Haihua;Gao Yue;Ren Zhonglu;Shi Yi-Wu;Li Sheng;Yu Yanhong;Zhong Mei;Yang Xinping
失调的RNA编辑在几种疾病中都有很好的记录，例如癌症和神经退行性疾病。RNA编辑可能在多大程度上参与了源于胎盘的疾病，目前尚不清楚。在这里，我们系统地分析了胎盘、9例早发性重度子痫前期(EOSPE)患者和32例正常人的RNA编辑组，并发现EOSPE中普遍存在RNA编辑失调。错误编辑的基因集富含已知的子痫前期相关基因和EOSPE中差异表达的基因。在LEPmRNA3‘-非翻译区的2个microRNA结合位点上产生了RNA编辑事件，可抑制microRNA诱导的胎盘来源细胞系LEPmRNA的下调，这与在子痫前期患者胎盘中的观察结果一致。这些结果证明了胎盘RNA编辑异常与子痫前期的关系，并为进一步研究RNA编辑在该病发病机制中的作用提供了资源。
Dysregulated RNA editing is well documented in several diseases, such as cancer and neurodegenerative diseases. The extent to which RNA editing might be involved in diseases originated in the placenta remains unknown. Here, we have systematically profiled RNA editome on the placentae, 9 from patients with early-onset severe preeclampsia (EOSPE) and 32 from normal subjects, and a widespread RNA editing dysregulation in EOSPE has been identified. The mis-edited gene set is enriched with known preeclampsia-associated genes and differentially expressed genes in EOSPE. The RNA editing events at 2 microRNA binding sites in 3′-untranslated region of theLEPmRNA were generated, which could inhibit the microRNA-induced mRNA downregulation ofLEPin placenta-derived cell line, consistent with the observation in the placentae of preeclampsia patients. These results demonstrate the association of dysregulated placental RNA editing with preeclampsia, and providing a resource for further study on the role of RNA editing in the pathogenesis of this disease.
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DOI：
10.1016/b978-0-12-809633-8.20106-4
发表时间：
2020-02
期刊：
--
影响因子：
--
作者：
A. Prjibelski;Anton I. Korobeynikov;Alla L. Lapidus
通讯作者：
A. Prjibelski;Anton I. Korobeynikov;Alla L. Lapidus
影响因子：
12.3
作者：
Middleton R;Gao D;Thomas A;Singh B;Au A;Wong JJ;Bomane A;Cosson B;Eyras E;Rasko JE;Ritchie W
通讯作者：
Ritchie W
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
6.7
作者：
Sagredo EA;Blanco A;Sagredo AI;Pérez P;Sepúlveda-Hermosilla G;Morales F;Müller B;Verdugo R;Marcelain K;Harismendy O;Armisén R
通讯作者：
Armisén R