Frontal Plane Knee Mechanics and Early Cartilage Degeneration in People With Anterior Cruciate Ligament Reconstruction: A Longitudinal Study.
Frontal Plane Knee Mechanics and Early Cartilage Degeneration in People With Anterior Cruciate Ligament Reconstruction: A Longitudinal Study.
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DOI：
10.1177/0363546517739605
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Kumar D;Su F;Wu D;Pedoia V;Heitkamp L;Ma CB;Souza RB;Li X
额平面步态力学是已知的膝骨关节炎（OA）的危险因素，但其在ACL重建（ACL- r）后早期软骨退变中的作用尚不清楚。目的是评估ACL-R受试者和对照组1年内额平面步态力学与膝关节内侧软骨磁共振（MR）放松时间的关系。我们假设(1)在ACL-R受试者中，随着时间的推移，膝关节正面内侧负荷和膝关节内侧MR放松时间会增加；(2)膝关节正面内侧负荷的增加将与膝关节内侧MR放松时间的增加有关。37例ACL-R患者在术前（BL）、ACL-R术后6个月（6M）和12个月（12M）分别行步态分析和双侧定量MRI检查。健康对照（n=13）进行BL和12M测定。步态变量包括膝关节内收峰值力矩（KAM）、膝关节内收峰值脉冲和膝关节内收峰值角。MRI变量包括股骨内侧（MF）和胫骨内侧（MT）全室和亚区域T1ρ和T2松弛时间。统计分析包括步态和MRI变量随时间变化的比较，步态和MRI变量随时间变化之间的相关性，以及KAM冲动增加和减少的受试者的MRI变量变化的差异。ACL-R组双膝内侧T1ρ （Δ 4-11%）和T2 （Δ 2-10%）从BL到6M显著升高，损伤膝内侧KAM （Δ 13%）显著升高。从BL到6M，损伤膝关节KAM冲量增加的受试者内侧T1ρ和T2比KAM冲量没有增加的受试者有更大的增加。对照组的纵向变化不显著。在ACL-R术后的前6个月，膝关节内侧放松次数增加。在前6个月，与没有增加内侧膝关节负荷的患者相比，内侧膝关节负荷增加的患者内侧膝关节放松时间增加。在ACL-R术后的前6个月内减少额平面负荷的策略可以减缓早期软骨退变。
Frontal plane gait mechanics are known risk factors for knee osteoarthritis (OA) but their role in early cartilage degeneration following ACL reconstruction (ACL-R) is not well understood. The objective was to evaluate the association of frontal plane gait mechanics with medial knee cartilage magnetic resonance (MR) relaxation times over 1-year in ACL-R subjects and controls. We hypothesized that (1) there will be an increase in frontal plane medial knee loading and medial knee MR relaxation times over time in the ACL-R subjects, and (2) increases in frontal plane medial knee loading will be associated with an increase in medial knee MR relaxation times. Cohort study Subjects with ACL-R (n=37) underwent walking gait analyses and bilateral quantitative MRI before surgery (BL) and at 6-month (6M) and 12-month (12M) after ACL-R. Healthy control subjects (n=13) were evaluated at BL and 12M. Gait variables included, peak knee adduction moment (KAM), knee KAM impulse, and peak knee adduction angle. MRI variables included medial femur (MF) and medial tibia (MT) whole-compartment and sub-regional T1ρ and T2 relaxation times. Statistical analyses included a comparison of changes over-time for gait and MRI variables, correlations between changes in gait and MRI variables over-time, and differences in change in MRI variables in subjects who showed an increase vs. decrease in KAM impulse. There were significant increases in medial T1ρ (Δ 4–11%) and T2 (Δ 2–10%) from BL to 6M for both knees in ACL-R group, and in KAM (Δ 13%) for the injured knee. From BL to 6M, subjects who had an increase in KAM impulse in the injured knee had a greater increase in medial T1ρ and T2 compared to those who did not have an increase in KAM impulse. Longitudinal changes for the control group were not significant. There is an increase in medial knee relaxation times over first 6-months after ACL-R. People with increase in medial knee loading show an increase in medial knee relaxation times compared to those who do not have an increase in medial knee loading over the first 6 months. Strategies to reduce frontal plane loading over the first 6-months following ACL-R may be investigated to slow early cartilage degeneration.
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影响因子：
10.9
作者：
Carballido-Gamio, Julio;Bauer, Jan S.;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila
影响因子：
2.8
作者：
Pedoia, Valentina;Su, Favian;Li, Xiaojuan
通讯作者：
Li, Xiaojuan
DOI：
10.1016/j.arthro.2013.09.075
发表时间：
2013-12-01
影响因子：
4.7
作者：
Li, Hong;Tao, Hongyue;Chen, Shiyi
通讯作者：
Chen, Shiyi
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
7
作者：
Li, X.;Benjamin, C.;Majumdar, S.
通讯作者：
Majumdar, S.