Interdependence of hypoxic and innate immune responses.
Interdependence of hypoxic and innate immune responses.
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DOI：
10.1038/nri2607
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发表时间：
2009-09
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影响因子：
--
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中科院分区：
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--
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缺氧诱导转录因子（Hypoxia-inducible transcription factor，HIF）是细胞代谢和适应缺氧引起的细胞应激的主要调节因子。吞噬细胞在抵抗病原体的先天免疫防御中起着至关重要的作用;这是一场主要发生在受感染组织的缺氧微环境中的战斗。现在已经清楚，HIF促进吞噬细胞的杀菌活性，并支持树突状细胞、肥大细胞和上皮细胞的先天免疫功能。针对微生物病原体，HIF表达通过涉及关键免疫应答调节因子核因子-κB的途径上调，突出了先天免疫和缺氧应答对感染和组织损伤的相互依赖性。反过来，HIF驱动的先天免疫反应对病原体和宿主都有重要影响，其在免疫防御中的核心作用表明了组织微环境在控制传染病中的重要性。
Hypoxia-inducible transcription factor (HIF) is a major regulator of cellular metabolism and adaptation to cellular stress caused by oxygen deficiency (hypoxia). Phagocytic cells have an essential role in innate immune defense against pathogens; and this is a battle that takes place mainly in the hypoxic microenvironments of infected tissues. It has now become clear that HIF promotes the bactericidal activities of phagocytic cells and supports the innate immune functions of dendritic cells, mast cells and epithelial cells. In response to microbial pathogens, HIF expression is upregulated through pathways involving the key immune response regulator nuclear factor-κB, highlighting an interdependence of the innate immune and hypoxic responses to infection and tissue damage. In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, and its central role in immune defence demonstrates the importance of the tissue microenvironment in controlling infectious disease.
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