Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice
Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice
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FTY720 在非肥胖糖尿病小鼠中预防自身免疫性糖尿病
DOI：
10.1097/00007890-200212270-00006
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发表时间：
2002
期刊：
影响因子：
6.2
通讯作者：
A. Monaco
中科院分区：
文献类型：
--
作者：
T. Maki;R. Gottschalk;A. Monaco
背景。FTY720能显著抑制同种异体移植物的排斥反应，且不引起全身免疫抑制。我们确定了FTY720对非肥胖糖尿病（NOD）小鼠自身免疫性糖尿病发展的影响。方法。从4周龄开始，给予NOD小鼠FTY720 （0.5 mg/kg，口服），每周5次。结果。在16只接受治疗的小鼠中，每天服用FTY720可以预防15只小鼠的糖尿病发展，而70%未经治疗的NOD小鼠在35周龄时患上糖尿病。在35周龄时停用FTY720导致5只小鼠在2周内发展为糖尿病，而其余小鼠在44周龄时保持无糖尿病状态。整个治疗期间未见药物副作用。FTY720还能预防环磷酰胺诱导的NOD小鼠糖尿病。结论。FTY720是一种安全、良性的治疗药物，可长期用于糖尿病前期患者。
Background. FTY720 prevents allograft rejection with remarkable potency without inducing generalized immunosuppression. We determined the effect of FTY720 on development of autoimmune diabetes in nonobese diabetic (NOD) mice. Methods. NOD mice were given FTY720 (0.5 mg/kg, orally) five times per week starting from 4 weeks of age. Results. Daily FTY720 prevented development of diabetes in 15 of 16 treated mice, whereas 70% of untreated NOD mice became diabetic by 35 weeks of age. Withdrawal of FTY720 at 35 weeks of age led to development of diabetes within 2 weeks in five mice, whereas the remaining mice maintained diabetes-free conditions for up to 44 weeks of age. No side effect of the drug was seen throughout the treatment period. FTY720 also prevented cyclophosphamide-induced diabetes in NOD mice. Conclusions. FTY720 is a safe and benign therapeutic agent that may be used chronically in prediabetic individuals.
影响因子：
56.9
作者：
SHIZURU, JA;TAYLOREDWARDS, C;FATHMAN, CG
通讯作者：
FATHMAN, CG