Retrospective estimation of the electric and magnetic field exposure conditions in in vitro experimental reports reveal considerable potential for uncertainty
Retrospective estimation of the electric and magnetic field exposure conditions in in vitro experimental reports reveal considerable potential for uncertainty
复制标题
体外实验报告中电场和磁场暴露条件的回顾性估计揭示了巨大的不确定性潜力
DOI：
10.1002/bem.22099
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发表时间：
2018
影响因子：
1.9
通讯作者：
J. Cuppen
中科院分区：
文献类型：
--
作者：
Lucas A Portelli;Karsten Falldorf;G. Thuróczy;J. Cuppen
暴露于极低频（ELF，3-300 Hz）磁场的细胞培养物实验通常会受到与特定电场和磁场暴露条件相关的多种不确定性来源的影响。在这里，我们系统地量化这些不确定性的暴露条件的基础上描述的一组生物电磁实验报告的现有文献的代表性抽样。由于实验方法和系统的描述、设计、实施或验证不充分、不明确或错误而产生的不确定性往往足以使原始实验条件的任何成功再现变得困难或不可能。在不对ELF电场和磁场的真实生物学相关性做出任何假设的情况下，这些发现表明另一个影响因素可能会增加传统上与体外暴露于低水平ELF磁场的实验结果相关的总体可变性和不可再现性。生物电磁学39：231-243，2018.© 2017 Wiley Periodicals，Inc.
Experiments on cell cultures exposed to extremely low frequency (ELF, 3–300 Hz) magnetic fields are often subject to multiple sources of uncertainty associated with specific electric and magnetic field exposure conditions. Here we systemically quantify these uncertainties based on exposure conditions described in a group of bioelectromagnetic experimental reports for a representative sampling of the existing literature. The resulting uncertainties, stemming from insufficient, ambiguous, or erroneous description, design, implementation, or validation of the experimental methods and systems, were often substantial enough to potentially make any successful reproduction of the original experimental conditions difficult or impossible. Without making any assumption about the true biological relevance of ELF electric and magnetic fields, these findings suggest another contributing factor which may add to the overall variability and irreproducibility traditionally associated with experimental results of in vitro exposures to low‐level ELF magnetic fields. Bioelectromagnetics. 39:231–243, 2018. © 2017 Wiley Periodicals, Inc.
暴露于极低频磁场的可兴奋细胞附近感应电流扰动的数值研究。
影响因子：
3.5
作者：
Hassan,Noha;Chatterjee,Indira;Publicover,NelsonG;Craviso,GaleL
通讯作者：
Craviso,GaleL