Numerical study of induced current perturbations in the vicinity of excitable cells exposed to extremely low frequency magnetic fields.
Numerical study of induced current perturbations in the vicinity of excitable cells exposed to extremely low frequency magnetic fields.
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暴露于极低频磁场的可兴奋细胞附近感应电流扰动的数值研究。
DOI：
10.1088/0031-9155/48/20/002
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发表时间：
2003
影响因子：
3.5
通讯作者：
Craviso,GaleL
中科院分区：
文献类型：
--
作者：
Hassan,Noha;Chatterjee,Indira;Publicover,NelsonG;Craviso,GaleL
模拟真实的三维细胞形态，以确定暴露于60 Hz磁场的可兴奋细胞培养物中诱导的电流密度，并确定可能影响细胞对这些磁场的反应的重要因素。细胞形态表示单个球形肾上腺嗜铬细胞，单个细长的平滑肌细胞和嗜铬细胞聚集体在含有培养基的培养皿中使用有限元法建模。球形细胞的计算揭示了细胞附近的感应电流密度的大小和空间分布的变化。最大值出现在赤道两侧，最小值出现在两极。细胞彼此的接近程度以及细胞聚集体的形状、大小和相对于感应电流的取向影响感应电流密度的大小和空间分布。对于一个细长的细胞，对感应电流密度的影响是高度依赖于细胞取向相对于感应电流的方向。这些结果提供了新的见解，在可兴奋的细胞培养制剂中发生的感应电流的扰动，并奠定了基础，了解极低频磁场在组织水平上的相互作用的机制。
Realistic three-dimensional cell morphologies were modelled to determine the current density induced in excitable cell culture preparations exposed to 60 Hz magnetic fields and to identify important factors that can influence the responses of cells to these fields. Cell morphologies representing single spherical adrenal chromaffin cells, single elongated smooth muscle cells and chromaffin cell aggregates in a Petri dish containing culture medium were modelled using the finite element method. The computations for a spherical cell revealed alterations in the magnitude and spatial distribution of the induced current density in the immediate vicinity of the cell. Maxima occurred at the equatorial sides and minima at the poles. Proximity of cells to each other as well as cell aggregate shape, size and orientation with respect to the induced current influenced the magnitude and spatial distribution of the induced current density. For an elongated cell, effects on the induced current density were highly dependent on cell orientation with respect to the direction of the induced current. These results provide novel insights into the perturbations in induced current that occur in excitable cell culture preparations and lay a foundation for understanding the mechanisms of interaction with extremely low frequency magnetic fields at the tissue level.
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对暴露于低频磁场的生物细胞中的感应电流进行建模。
影响因子：
3.5
作者：
M. Stuchly;W. Xi
通讯作者：
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影响因子：
1.9
作者：
Chatterjee, I;Hassan, N;Publicover, NG
通讯作者：
Publicover, NG
影响因子：
1.9
作者：
KANJE, M;RUSOVAN, A;LUNDBORG, G
通讯作者：
LUNDBORG, G
影响因子：
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作者：
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共聚焦显微镜揭示培养嗜铬细胞胞吐作用的优先极
影响因子：
3.5
作者：
I. Cuchillo;P. Michelena;A. Albillos;Antonio G. García
通讯作者：
Antonio G. García