Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons.
Cell-Biological Requirements for the Generation of Dentate Gyrus Granule Neurons.
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DOI：
10.3389/fncel.2018.00402
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发表时间：
2018
影响因子：
5.3
通讯作者：
Skutella T
中科院分区：
文献类型：
--
作者：
Hatami M;Conrad S;Naghsh P;Alvarez-Bolado G;Skutella T
齿状回（DG）从功能上集成在三突触海马回路中的联想皮层接收高度处理的信息，这有助于新情景记忆的形成和对新环境的自发探索。值得注意的是，DG 是目前已知的成人中唯一具有高神经发生率的大脑区域（Andersen 等人）。 DG 与多种神经退行性疾病有关，包括临床痴呆、精神分裂症、抑郁症、双向情感障碍和颞叶癫痫。 DG 的主要神经元是颗粒细胞。培养物中产生的 DG 颗粒细胞将是研究其正常发育、其所涉及的病理原因以及可能的治疗方法的理想模型。建立此类体外模型的关键是准确定义 DG 颗粒细胞分化最重要的细胞生物学要求。这需要更深入地了解体内 DG 颗粒细胞以及体外衍生的 DG 细胞的精确分子和功能属性。在这篇综述中，我们概述了颗粒细胞分化途径的神经解剖学、分子和细胞生物学组成部分，包括对其发育至关重要的一些生长和转录因子。我们总结了DG颗粒神经元的功能特征，包括未成熟和成熟颗粒细胞的电生理特征以及DG神经元的轴突寻路特征。此外，我们还讨论了从多能干细胞 (PSC) 生成背侧端脑前体细胞以及培养中的 DG 神经元分化的里程碑式研究。最后，我们提供展望并评论关键方面。
The dentate gyrus (DG) receives highly processed information from the associative cortices functionally integrated in the trisynaptic hippocampal circuit, which contributes to the formation of new episodic memories and the spontaneous exploration of novel environments. Remarkably, the DG is the only brain region currently known to have high rates of neurogenesis in adults (Andersen et al.,). The DG is involved in several neurodegenerative disorders, including clinical dementia, schizophrenia, depression, bipolar disorder and temporal lobe epilepsy. The principal neurons of the DG are the granule cells. DG granule cells generated in culture would be an ideal model to investigate their normal development and the causes of the pathologies in which they are involved and as well as possible therapies. Essential to establish such in vitro models is the precise definition of the most important cell-biological requirements for the differentiation of DG granule cells. This requires a deeper understanding of the precise molecular and functional attributes of the DG granule cells in vivo as well as the DG cells derived in vitro. In this review we outline the neuroanatomical, molecular and cell-biological components of the granule cell differentiation pathway, including some growth- and transcription factors essential for their development. We summarize the functional characteristics of DG granule neurons, including the electrophysiological features of immature and mature granule cells and the axonal pathfinding characteristics of DG neurons. Additionally, we discuss landmark studies on the generation of dorsal telencephalic precursors from pluripotent stem cells (PSCs) as well as DG neuron differentiation in culture. Finally, we provide an outlook and comment critical aspects.
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DOI：
10.1073/pnas.0910786107
发表时间：
2010-06-08
影响因子：
11.1
作者：
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通讯作者：
Millen, Kathleen J.
影响因子：
2.5
作者：
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影响因子：
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作者：
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通讯作者：
Bock, Hans H.
影响因子：
5.3
作者：
Cheng, Xun;Hsu, Ching-mei;Monuki, Edwin S.
通讯作者：
Monuki, Edwin S.
DOI：
10.1523/jneurosci.0128-13.2013
发表时间：
2013-04-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Choe Y;Kozlova A;Graf D;Pleasure SJ
通讯作者：
Pleasure SJ