Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota.
Impact of a Model Used to Simulate Chronic Socio-Environmental Stressors Encountered during Spaceflight on Murine Intestinal Microbiota.
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用于模拟航天期间遇到的慢性社会环境应激源的模型对小鼠肠道微生物区系的影响。
DOI：
10.3390/ijms21217863
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发表时间：
2020-10-23
影响因子：
5.6
通讯作者：
Frippiat JP
中科院分区：
文献类型：
--
作者：
Alauzet C;Cunat L;Wack M;Lanfumey L;Legrand-Frossi C;Lozniewski A;Agrinier N;Cailliez-Grimal C;Frippiat JP
在深空旅行中，机组人员面临着各种身体和心理社会压力，这些压力可能会改变肠道微生物区系的组成。由于众所周知，肠道微生物失调与几种疾病的发生或恶化有关，本研究的目的是在模拟长期太空任务中遇到的慢性心理社会应激源的小鼠模型中评估肠道微生物区系的变化。我们证明，暴露在这种模型(称为慢性不可预测的温和应激)的3周内，盲肠内β多样性发生了显着变化，其特征是菲米库特/拟杆菌比率的显著增加。这些变化与卟啉单胞菌科的减少有关，特别是巴氏杆菌属，这是小鼠和人类肠道微生物区系的主要成员，在那里它被描述为具有保护特性。这些结果提出了压力导致有益类群减少的影响的问题，支持了从飞行实验和其他地面模型得出的最新数据，并强调了迫切需要进一步研究探索航天对肠道微生物区系的影响，以便提出应对航天相关的生态失调及其对健康影响的策略。
During deep-space travels, crewmembers face various physical and psychosocial stressors that could alter gut microbiota composition. Since it is well known that intestinal dysbiosis is involved in the onset or exacerbation of several disorders, the aim of this study was to evaluate changes in intestinal microbiota in a murine model used to mimic chronic psychosocial stressors encountered during a long-term space mission. We demonstrate that 3 weeks of exposure to this model (called CUMS for Chronic Unpredictable Mild Stress) induce significant change in intracaecal β-diversity characterized by an important increase of the Firmicutes/Bacteroidetes ratio. These alterations are associated with a decrease of Porphyromonadaceae, particularly of the genus Barnesiella, a major member of gut microbiota in mice and humans where it is described as having protective properties. These results raise the question of the impact of stress-induced decrease of beneficial taxa, support recent data deduced from in-flight experimentations and other ground-based models, and emphasize the critical need for further studies exploring the impact of spaceflight on intestinal microbiota in order to propose strategies to countermeasure spaceflight-associated dysbiosis and its consequences on health.
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影响因子：
14.9
作者：
Klindworth A;Pruesse E;Schweer T;Peplies J;Quast C;Horn M;Glöckner FO
通讯作者：
Glöckner FO
影响因子：
4.8
作者：
Fonte, Coralie;Kaminski, Sandra;Frippiat, Jean-Pol
通讯作者：
Frippiat, Jean-Pol
影响因子：
5.2
作者：
Geng, Shaohui;Yang, Liping;Zhang, Jingtao
通讯作者：
Zhang, Jingtao
影响因子：
2.2
作者：
Ferrand, Janina;Patron, Kevin;Lozniewski, Alain
通讯作者：
Lozniewski, Alain
影响因子：
4.3
作者：
Huson DH;Beier S;Flade I;Górska A;El-Hadidi M;Mitra S;Ruscheweyh HJ;Tappu R
通讯作者：
Tappu R