Making Knowledge in Synthetic Biology: Design Meets Kludge
Making Knowledge in Synthetic Biology: Design Meets Kludge
复制标题
创造合成生物学知识：设计与拼凑的结合
DOI：
10.1162/biot_a_00006
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Maureen A. O’Malley
中科院分区：
文献类型：
--
作者：
Maureen A. O’Malley
合成生物学是一个涵盖一系列目标、方法和技术的总称。它们都是通过类比、综合、机械化和组装等共同实践而聚集在一起的。重点放在组装作为生物学，工程学和进化之间的连接点，我展示了合成生物学的成功如何依赖于定制的组装和创造性的，“使它工作”的态度来构建生物系统。然而，这种做法并不完全符合合成生物学对理性设计的颂扬。它们也没有直截了当地体现理查德·费曼的“最后一块黑板”的声明（1988），即不创造一些东西就不能理解。进一步反思综合建构与知识创造的关系，为科学哲学提供了洞察科学实践的新途径。
Synthetic biology is an umbrella term that covers a range of aims, approaches, and techniques. They are all brought together by common practices of analogizing, synthesizing, mechanicizing, and kludging. With a focus on kludging as the connection point between biology, engineering, and evolution, I show how synthetic biology’s successes depend on custom-built kludges and a creative, “make-it-work” attitude to the construction of biological systems. Such practices do not fit neatly, however, into synthetic biology’s celebration of rational design. Nor do they straightforwardly embody Richard Feynman’s “last blackboard” statement (1988) that without creating something it cannot be understood. Reflecting further on the relationship between synthetic construction and knowledge making gives philosophy of science new avenues of insight into scientific practice.
影响因子：
7.5
作者：
P. Sorger
通讯作者：
P. Sorger