Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression.
Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression.
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DOI：
10.1371/journal.pone.0250987
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Price RW
中科院分区：
文献类型：
--
作者：
Gisslen M;Keating SM;Spudich S;Arechiga V;Stephenson S;Zetterberg H;Di Germanio C;Blennow K;Fuchs D;Hagberg L;Norris PJ;Peterson J;Shacklett BL;Yiannoutsos CT;Price RW
将一组脑脊液（CSF）炎症生物标志物应用于代表广谱全身性HIV-1免疫抑制、CNS损伤和病毒控制的分组受试者，以表征HIV-1感染中中枢神经系统（CNS）炎症的演变。这是对存档的CSF和血液样本的横断面分析，通过免疫测定法评估143名HIV-1感染受试者中10种功能多样的可溶性炎症生物标志物的浓度，这些受试者被分为8组：未经治疗的原发性HIV-1感染（PHI）; 4个未经治疗的组，由他们的血液CD 4 + T淋巴细胞计数定义;未经治疗的亚急性HIV相关痴呆（HAD）患者;血浆病毒抑制≥1年的抗逆转录病毒治疗受试者;和未接受治疗的精英控制者。包括20个HIV-1未感染的对照用于比较。背景生物标志物包括血液CD 4+和CD 8 + T淋巴细胞、CSF和血液HIV-1 RNA、CSF白色血细胞（WBC）计数、CSF/血液白蛋白比值、CSF神经丝轻链（NfL）和CSF t-tau。HIV-1感染与广泛的CSF炎性反应相关，该反应在病程早期发生，并随着全身疾病进展、神经损伤的发生和病毒抑制而变化。在没有明显HAD的未治疗个体中，CSF炎症表现出至少两种总体炎症模式，因为血液CD 4 + T淋巴细胞减少：一种在200-350血液CD 4 + T细胞/μL时达到峰值，并与淋巴细胞CSF炎症和HIV-1 RNA浓度相关;第二种是在整个CD 4 + T细胞下降过程中稳定增加，并与巨噬细胞反应和增加CNS损伤有关。亚急性HAD的特点是第三种炎症特征，血脑屏障通透性增加，淋巴细胞和巨噬细胞CSF炎症强烈。通过抗逆转录病毒治疗和精英病毒控制抑制CSF和血液HIV-1感染与CSF炎症减少相关，但未完全达到HIV-1血清阴性对照的水平。
To characterize the evolution of central nervous system (CNS) inflammation in HIV-1 infection applying a panel of cerebrospinal fluid (CSF) inflammatory biomarkers to grouped subjects representing a broad spectrum of systemic HIV-1 immune suppression, CNS injury and viral control. This is a cross-sectional analysis of archived CSF and blood samples, assessing concentrations of 10 functionally diverse soluble inflammatory biomarkers by immunoassays in 143 HIV-1-infected subjects divided into 8 groups: untreated primary HIV-1 infection (PHI); four untreated groups defined by their blood CD4+ T lymphocyte counts; untreated patients presenting with subacute HIV-associated dementia (HAD); antiretroviral-treated subjects with ≥1 years of plasma viral suppression; and untreated elite controllers. Twenty HIV-1-uninfected controls were included for comparison. Background biomarkers included blood CD4+ and CD8+ T lymphocytes, CSF and blood HIV-1 RNA, CSF white blood cell (WBC) count, CSF/blood albumin ratio, CSF neurofilament light chain (NfL), and CSF t-tau. HIV-1 infection was associated with a broad compartmentalized CSF inflammatory response that developed early in its course and changed with systemic disease progression, development of neurological injury, and viral suppression. CSF inflammation in untreated individuals without overt HAD exhibited at least two overall patterns of inflammation as blood CD4+ T lymphocytes decreased: one that peaked at 200–350 blood CD4+ T cells/μL and associated with lymphocytic CSF inflammation and HIV-1 RNA concentrations; and a second that steadily increased through the full range of CD4+ T cell decline and associated with macrophage responses and increasing CNS injury. Subacute HAD was distinguished by a third inflammatory profile with increased blood-brain barrier permeability and robust combined lymphocytic and macrophage CSF inflammation. Suppression of CSF and blood HIV-1 infections by antiretroviral treatment and elite viral control were associated with reduced CSF inflammation, though not fully to levels found in HIV-1 seronegative controls.
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影响因子：
4.6
作者：
Arrildt, Kathryn Twigg;Joseph, Sarah Beth;Swanstrom, Ronald
通讯作者：
Swanstrom, Ronald
DOI：
10.1097/qai.0000000000000532
发表时间：
2015-05-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Anderson AM;Harezlak J;Bharti A;Mi D;Taylor MJ;Daar ES;Schifitto G;Zhong J;Alger JR;Brown MS;Singer EJ;Campbell TB;McMahon DD;Buchthal S;Cohen R;Yiannoutsos C;Letendre SL;Navia BA;HIV Neuroimaging Consortium
通讯作者：
HIV Neuroimaging Consortium
影响因子：
11.2
作者：
Ellis, RJ;Hsia, K;Dupont, R
通讯作者：
Dupont, R
影响因子：
3.8
作者：
Dahl, Viktor;Peterson, Julia;Price, Richard W.
通讯作者：
Price, Richard W.
影响因子：
11.2
作者：
BREW, BJ;ROSENBLUM, M;PRICE, RW
通讯作者：
PRICE, RW