The Drosophila cdc25 homolog twine is required for meiosis.
The Drosophila cdc25 homolog twine is required for meiosis.
复制标题
果蝇 cdc25 同源线是减数分裂所必需的。
作者：
Catherine Courtot;C. Fankhauser;V. Simanis;C. Lehner
我们已经在果蝇中发现了第二个cdc25同源物。与string（在果蝇中发现的第一个同源物）相反，第二个同源物twine在有丝分裂细胞周期中不起作用，但专门用于减数分裂。twine在雄性和雌性性腺中均有表达。麻绳转录本在减数分裂期间存在于生殖细胞中，仅在配子体发生后期出现，在有丝分裂生殖细胞分裂结束后很久才出现。无菌果蝇突变体mat(2)synHB5，先前已被分离并定位到与twine （35F）相同的基因组区域，被发现在twine基因中携带一个错义突变。麻花菌的这种错义突变使其丧失了补充裂糖菌cdc25突变的能力。对mat(2)synHB5突变体果蝇的表型分析显示，雄性果蝇减数分裂完全阻断，雌性果蝇减数分裂存在严重缺陷。
We have identified a second cdc25 homolog in Drosophila. In contrast to string (the first homolog identified in Drosophila) this second homolog, twine, does not function in the mitotic cell cycle, but is specialized for meiosis. Expression of twine was observed exclusively in male and female gonads. twine transcripts are present in germ cells during meiosis, and appear only late during gametogenesis, well after the end of the mitotic germ cell divisions. The sterile Drosophila mutant, mat(2)synHB5, which had previously been isolated and mapped to the same genomic region as twine (35F), was found to carry a missense mutation in the twine gene. This missense mutation in twine abolished its ability to complement a mutation in Schizosaccharomyces pombe cdc25. Phenotypic analysis of mat(2)synHB5 mutant flies revealed a complete block of meiosis in males and severe meiotic defects in females.
DOI：
10.1073/pnas.87.13.5139
发表时间：
1990-07-01
影响因子：
11.1
作者：
SADHU, K;REED, SI;RUSSELL, P
通讯作者：
RUSSELL, P
影响因子：
3.3
作者：
Trudi Schüpbach;Eric Wieschaus
通讯作者：
Trudi Schüpbach;Eric Wieschaus
影响因子：
11.4
作者：
ELLEDGE, SJ;SPOTTSWOOD, MR
通讯作者：
SPOTTSWOOD, MR