The role of CRF in the release of ACTH by opiate agonists and antagonists in rats
The role of CRF in the release of ACTH by opiate agonists and antagonists in rats
复制标题
CRF在大鼠阿片激动剂和拮抗剂释放ACTH中的作用
DOI：
10.1016/0006-8993(87)91311-4
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
A. Herz
中科院分区：
文献类型：
--
作者：
K. Nikolarakis;A. Pfeiffer;G. Stalla;A. Herz
阿片激动剂和阿片拮抗剂通过未知的中枢机制释放促肾上腺皮质激素（ACTH）。我们研究了促肾上腺皮质激素释放因子（CRF）在阿片类药物对ACTH释放的作用。大鼠在注射阿片类拮抗剂纳洛酮或阿片类激动剂吗啡（μ受体激动剂）或mr2034 （k受体激动剂）之前，先用抗大鼠CRF特异性血清（r-CRF）预处理。这消除了纳洛酮或泰克激动剂引起的ACTH增加。然而，μ激动剂吗啡引起对照或r-CRF抗血清处理大鼠ACTH显著增加。我们得出结论：(a)内源性阿片类药物强直性抑制CRF的释放，(b)k-激动剂刺激CRF的释放，(c) μ-激动剂通过与CRF无关的机制释放ACTH。
Opiate agonists as well as opiate antagonists release adrenocorticotropic hormone (ACTH) through unknown central mechanisms. We examined the role of corticotropin releasing factor (CRF) in opioid actions on ACTH release. Rats were pretreated with a specific antiserum to rat CRF (r-CRF) prior to injection of the opiate antagonist naloxone or the opiate agonists morphine (μ-receptor agonist) or MR 2034 (k-receptor agonist). This abolished the increase in ACTH caused by naloxone or by thek-agonist. The μ-agonist morphine, however, caused a significant increase in ACTH in control-or r-CRF antiserum treated rats. We conclude that (a) endogenous opioids tonically inhibit the release of CRF, (b)k-agonists stimulate the release of CRF, and (c) μ-agonists release ACTH by acting additionally through CRF-independent mechanisms.
DOI：
10.1073/pnas.80.15.4851
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
RIVIER, J;SPIESS, J;VALE, W
通讯作者：
VALE, W
通过神经递质、神经肽和渗透刺激调节加压素的释放。
影响因子：
--
作者：
Sladek,CD
通讯作者：
Sladek,CD