Salmonella - at home in the host cell.

Salmonella - at home in the host cell.
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DOI:
10.3389/fmicb.2011.00125
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发表时间:
2011
影响因子:
5.2
通讯作者:
Steele-Mortimer O
Steele-Mortimer O
中科院分区:
生物学2区
文献类型:
--
作者:
Malik-Kale P;Jolly CE;Lathrop S;Winfree S;Luterbach C;Steele-Mortimer O

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革兰氏阴性细菌肠道沙门氏菌(Salmonella enterica)已经开发了一系列复杂的工具来操纵宿主细胞并建立细胞内生态位,以作为兼性细胞内病原体成功繁殖。虽然沙门氏菌对其宿主细胞产生不同的影响,但只有经典的“触发”介导的入侵过程的细胞生物学和随后的含沙门氏菌的液泡的发展被广泛研究。这些过程依赖于通过两个III型分泌系统(T3SS)易位到宿主细胞中的效应蛋白的队列,尽管T3SS独立的进入机制对于某些宿主细胞类型的入侵可能是重要的。最近对沙门氏菌细胞内生活方式的研究为这种病原体调节其细胞内环境的机制提供了新的见解。在这里,我们讨论目前的知识沙门氏菌宿主相互作用,包括入侵和建立一个细胞内的小生境内的主机。
The Gram-negative bacterium Salmonella enterica has developed an array of sophisticated tools to manipulate the host cell and establish an intracellular niche, for successful propagation as a facultative intracellular pathogen. While Salmonella exerts diverse effects on its host cell, only the cell biology of the classic “trigger”-mediated invasion process and the subsequent development of the Salmonella-containing vacuole have been investigated extensively. These processes are dependent on cohorts of effector proteins translocated into host cells by two type III secretion systems (T3SS), although T3SS-independent mechanisms of entry may be important for invasion of certain host cell types. Recent studies into the intracellular lifestyle of Salmonella have provided new insights into the mechanisms used by this pathogen to modulate its intracellular environment. Here we discuss current knowledge of Salmonella-host interactions including invasion and establishment of an intracellular niche within the host.
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