Recreational physical activity, body mass index, and survival in women with colorectal cancer.
Recreational physical activity, body mass index, and survival in women with colorectal cancer.
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结直肠癌女性的休闲体育锻炼，体重指数和生存。
DOI：
10.1007/s10552-012-0071-2
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发表时间：
2012-12
影响因子：
2.3
通讯作者：
Newcomb, Polly A.
中科院分区：
文献类型：
--
作者：
Kuiper, Josephina G.;Phipps, Amanda I.;Neuhouser, Marian L.;Chlebowski, Rowan T.;Thomson, Cynthia A.;Irwin, Melinda L.;Lane, Dorothy S.;Wactawski-Wende, Jean;Hou, Lifang;Jackson, Rebecca D.;Kampman, Ellen;Newcomb, Polly A.
此前的研究表明，缺乏体育活动和肥胖是结直肠癌发展的危险因素。然而，关于这些因素对结直肠癌患者生存的影响还存在争议。我们评估了在结直肠癌诊断前后休闲体育活动和身体质量指数(BMI)对疾病特异性死亡率和全因死亡率的影响。这项前瞻性队列研究包括1339名在妇女健康倡议研究中登记的妇女，她们在研究登记后被诊断为结直肠癌。BMI和娱乐性体力活动在癌症诊断前、研究开始时(诊断前)和诊断后在研究随访中(诊断后)进行了测量。我们使用COX回归来评估诊断前和诊断后暴露与结直肠癌诊断后生存率之间的关系。在被诊断为结直肠癌的女性中，265例(13%)死亡发生在11.9年的中位研究随访期内，其中171例(65%)被归因于结直肠癌。与那些报告诊断前没有休闲体育活动的妇女相比，那些报告≥每周18个小时的活动水平的妇女的结直肠癌特异性死亡率(危险比(HR)=0.68；95%可信区间(CI)：0.41-1.13)和全因死亡率(HR=0.63；95%CI：0.42-0.96)显著降低。在诊断后的娱乐性体力活动中也发现了类似的反向关联。诊断前和诊断后的BMI与结直肠癌诊断后的死亡率均无相关性。在CR结直肠癌C诊断前后进行娱乐性体力活动，而不是BMI，与更有利的生存相关。
Previous studies have shown that physical inactivity and obesity are risk factors for the development of colorectal cancer. However, controversy exists regarding the influence of these factors on survival in colorectal cancer patients. We evaluated the impact of recreational physical activity and body mass index (BMI) before and after colorectal cancer diagnosis on disease-specific mortality and all-cause mortality. This prospective cohort study included 1339 women enrolled in the Women’s Health Initiative study who were diagnosed with colorectal cancer subsequent to study enrolment. BMI and recreational physical activity were measured before cancer diagnosis at study entry (pre-diagnostic) and after diagnosis at study follow-up interviews (post-diagnostic). We used Cox regression to estimate the association between pre- and post-diagnostic exposures and survival after colorectal cancer diagnosis. Among women diagnosed with colorectal cancer, 265 (13%) deaths occurred during a median study follow-up of 11.9 years, of which 171 (65%) were attributed to colorectal cancer. Compared with women reporting no pre-diagnostic recreational physical activity, those reporting activity levels of ≥18 MET-hours/week had significantly lower colorectal cancer-specific mortality (hazard ratio (HR)=0.68; 95% confidence interval (CI): 0.41–1.13) and all-cause mortality (HR=0.63; 95% CI: 0.42–0.96). Similar inverse associations were seen for post-diagnostic recreational physical activity. Neither pre- nor post-diagnostic BMI were associated with mortality after colorectal cancer diagnosis. Recreational physical activity before and after CR colorectal cancer C diagnosis, but not BMI, is associated with more favourable survival.
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影响因子：
2.3
作者：
Johnson-Kozlow, Marilyn;Rock, Cheryl L.;Pierce, John P.
通讯作者：
Pierce, John P.
影响因子：
24.5
作者：
Dray, X;Boutron-Ruault, MC;Faivre, J
通讯作者：
Faivre, J
DOI：
10.1158/1940-6207.capr-10-0295
发表时间：
2011-04
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Irwin ML;McTiernan A;Manson JE;Thomson CA;Sternfeld B;Stefanick ML;Wactawski-Wende J;Craft L;Lane D;Martin LW;Chlebowski R
通讯作者：
Chlebowski R
影响因子：
2.3
作者：
Lin, J;Zhang, SM;Buring, JE
通讯作者：
Buring, JE
影响因子：
3.8
作者：
Friedenreich, Christine;Norat, Teresa;Riboli, Elio
通讯作者：
Riboli, Elio