Pathology and Pathogenesis of Adenomyosis.
Pathology and Pathogenesis of Adenomyosis.
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DOI：
10.1055/s-0040-1718922
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发表时间：
2020-05
影响因子：
2.7
通讯作者：
Shih IM
中科院分区：
文献类型：
--
作者：
Antero MF;Ayhan A;Segars J;Shih IM
子宫腺肌病是一种独特的病理生理状态，表现为正常的子宫内膜粘膜存在于子宫肌层内，从而防止月经脱落。由此产生的由腺体和间质组成的子宫内膜组织的异位存在被认为会影响子宫平滑肌的正常收缩功能和增生，导致月经过多、不孕和不良产科结局。自从150多年前第一次描述子宫腺肌病以来，病理学家通过检查组织标本来研究这种病变，并提出了多种解释来解释其发病机制。然而，与子宫内膜异位症相比，子宫腺肌病的研究进展最多只能说是渐进式的，这主要是由于缺乏标准化的组织取样方案和病理学实践中缺乏共识的诊断标准。尽管存在这些局限性，但最近在揭示在位子宫内膜的详细解剖学和生物学方面的进展为研究这种常见但研究相对不足的疾病提供了前所未有的机会。在这里，我们简要地总结了子宫腺肌病的病理方面的历史背景，并讨论了传统的形态学和最近的组织为基础的分子研究，特别强调从病理学家的角度阐明其组织起源。我们还讨论了病理学研究中未满足的需求，这对推进子宫腺肌病研究很重要。
Adenomyosis represents a unique pathophysiological condition in which normal-appearing endometrial mucosa resides within myometrium and is thus protected from menstrual shedding. The resulting ectopic presence of endometrial tissue composed of glands and stroma is thought to affect normal contractile function and peristalsis of uterine smooth muscle, causing menometrorrhagia, infertility, and adverse obstetric outcomes. Since the first description of adenomyosis more than 150 years ago, pathologists have studied this lesion by examining tissue specimens, and have proposed multiple explanations to account for its pathogenesis. However, as compared with endometriosis, progress of adenomyosis research has been, at best, incremental mainly due to the lack of standardized protocols in sampling tissue and a lack of consensus diagnostic criteria in pathology practice. Despite these limitations, recent advances in revealing the detailed anatomy and biology of eutopic endometrium offer an unprecedented opportunity to study this common but relatively understudied disorder. Here, we briefly summarize the pathological aspects of adenomyosis from an historical background, and discuss conventional morphology and recent tissue-based molecular studies with a special emphasis on elucidating its tissue of origin from a pathologist’s perspective. We also discuss unmet needs in pathology studies that would be important for advancing adenomyosis research.
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DOI：
10.1056/nejmoa1614814
发表时间：
2017-05-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Anglesio MS;Papadopoulos N;Ayhan A;Nazeran TM;Noë M;Horlings HM;Lum A;Jones S;Senz J;Seckin T;Ho J;Wu RC;Lac V;Ogawa H;Tessier-Cloutier B;Alhassan R;Wang A;Wang Y;Cohen JD;Wong F;Hasanovic A;Orr N;Zhang M;Popoli M;McMahon W;Wood LD;Mattox A;Allaire C;Segars J;Williams C;Tomasetti C;Boyd N;Kinzler KW;Gilks CB;Diaz L;Wang TL;Vogelstein B;Yong PJ;Huntsman DG;Shih IM
通讯作者：
Shih IM
DOI：
10.1097/pgp.0b013e318182c2be
发表时间：
2009-03-01
影响因子：
2.4
作者：
Goteri, Gaia;Lucarini, Guendalina;Ciavattini, Andrea
通讯作者：
Ciavattini, Andrea
DOI：
10.1016/0002-9378(72)90781-8
发表时间：
1972-01-01
影响因子：
9.8
作者：
BIRD, CC;MCELIN, TW;MANALOES.P
通讯作者：
MANALOES.P
DOI：
10.1016/s0002-9378(25)90632-1
发表时间：
1925-07-01
影响因子：
9.8
作者：
Frankl, O
通讯作者：
Frankl, O
影响因子：
7.1
作者：
Exacoustos, C.;Brienza, L.;Arduini, D.
通讯作者：
Arduini, D.