Unraveling the Fecal Microbiota and Metagenomic Functional Capacity Associated with Feed Efficiency in Pigs.
Unraveling the Fecal Microbiota and Metagenomic Functional Capacity Associated with Feed Efficiency in Pigs.
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DOI：
10.3389/fmicb.2017.01555
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发表时间：
2017
影响因子：
5.2
通讯作者：
Huang L
中科院分区：
文献类型：
--
作者：
Yang H;Huang X;Fang S;He M;Zhao Y;Wu Z;Yang M;Zhang Z;Chen C;Huang L
肠道微生物群在能量收获、营养消化和肠道健康中起着重要作用，特别是在处理饮食中的多糖的难消化成分中。揭示与饲料效率相关的肠道微生物类群和功能能力，可以为养猪业提高猪饲料效率提供重要的知识。在本研究中，我们研究了280头商品杜洛克猪的粪便微生物群与饲料效率的关系。所有试验猪可分为两个肠型群。不同肠型与饲料转化率呈相关趋势（P = 0.07）。我们进一步确定了31个操作分类单位（OTU），显示出与猪饲料效率的潜在关联。这些OTU主要注释与膳食多糖代谢相关的细菌。虽然我们没有在FDR < 0.05水平鉴定出RFI相关的细菌物种，但宏基因组测序分析确实发现了高RFI猪和低RFI猪（FDR < 0.05）之间肠道微生物组的不同功能能力。与氮代谢、氨基酸代谢和转运系统相关的KEGG同源性以及甘氨酸、丝氨酸和苏氨酸代谢等8条KEGG途径与猪饲料效率呈正相关。由此推测，肠道菌群可能通过发酵饲粮多糖产生SCFAs促进肠道健康，提高饲粮蛋白质利用率，从而提高猪饲料利用率。本研究结果为通过调控肠道微生物菌群提高猪饲料效率提供了重要的基础知识。
Gut microbiota plays fundamental roles in energy harvest, nutrient digestion, and intestinal health, especially in processing indigestible components of polysaccharides in diet. Unraveling the microbial taxa and functional capacity of gut microbiome associated with feed efficiency can provide important knowledge to improve pig feed efficiency in swine industry. In the current research, we studied the association of fecal microbiota with feed efficiency in 280 commercial Duroc pigs. All experimental pigs could be clustered into two enterotype-like groups. Different enterotypes showed the tendency of association with the feed efficiency (P = 0.07). We further identified 31 operational taxonomic units (OTUs) showing the potential associations with porcine feed efficiency. These OTUs were mainly annotated to the bacteria related to the metabolisms of dietary polysaccharides. Although we did not identify the RFI-associated bacterial species at FDR < 0.05 level, metagenomic sequencing analysis did find the distinct function capacities of gut microbiome between the high and low RFI pigs (FDR < 0.05). The KEGG orthologies related to nitrogen metabolism, amino acid metabolism, and transport system, and eight KEGG pathways including glycine, serine, and threonine metabolism were positively associated with porcine feed efficiency. We inferred that gut microbiota might improve porcine feed efficiency through promoting intestinal health by the SCFAs produced by fermenting dietary polysaccharides and improving the utilization of dietary protein. The present results provided important basic knowledge for improving porcine feed efficiency through modulating gut microbiome.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
15.5
作者：
Fadrosh DW;Ma B;Gajer P;Sengamalay N;Ott S;Brotman RM;Ravel J
通讯作者：
Ravel J
DOI：
10.1017/s175173111600286x
发表时间：
2017-09
期刊：
Animal : an international journal of animal bioscience
影响因子：
--
作者：
Gilbert H;Billon Y;Brossard L;Faure J;Gatellier P;Gondret F;Labussière E;Lebret B;Lefaucheur L;Le Floch N;Louveau I;Merlot E;Meunier-Salaün MC;Montagne L;Mormede P;Renaudeau D;Riquet J;Rogel-Gaillard C;van Milgen J;Vincent A;Noblet J
通讯作者：
Noblet J
DOI：
10.1073/pnas.1116053109
发表时间：
2012-01-10
影响因子：
11.1
作者：
Greenblum, Sharon;Turnbaugh, Peter J.;Borenstein, Elhanan
通讯作者：
Borenstein, Elhanan
影响因子：
20.1
作者：
Fu J;Bonder MJ;Cenit MC;Tigchelaar EF;Maatman A;Dekens JA;Brandsma E;Marczynska J;Imhann F;Weersma RK;Franke L;Poon TW;Xavier RJ;Gevers D;Hofker MH;Wijmenga C;Zhernakova A
通讯作者：
Zhernakova A