Cycles of goal silencing and reactivation underlie complex problem-solving in primate frontal and parietal cortex.
Cycles of goal silencing and reactivation underlie complex problem-solving in primate frontal and parietal cortex.
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DOI：
10.1038/s41467-023-40676-1
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发表时间：
2023-08-19
影响因子：
16.6
通讯作者：
Duncan, John
中科院分区：
文献类型：
--
作者：
Watanabe, Kei;Kadohisa, Mikiko;Kusunoki, Makoto;Buckley, Mark J.;Duncan, John
虽然经典观点认为工作记忆（WM）是由持续放电介导的，但最近的证据表明活动沉默状态的贡献。在工作记忆中，人类神经影像学研究表明，注意力在前景和背景之间切换，只有前景项目在活跃的神经放电中表现出来。为了在细胞水平上解决这一过程，我们在一个复杂的问题解决任务中记录了前额叶（PFC）和后顶叶（PPC）神经元，猴子在第一个试验周期中搜索一个或两个目标位置，并在随后的周期中保留它们用于记忆引导的重访。当目标位置被发现时，额叶和顶叶神经元都没有显示持续的目标位置代码，并持续到随后的试验和循环中。相反，有一系列及时的目标沉默和重新激活，以及重新激活后的持续状态，直到行为反应。对于两个目标位置，两个区域的目标表征都显示出前景和背景之间的过渡，但PFC表征更完整，超出了当前试验的范围，包括过去和未来的选择。在没有完整的持续代码的情况下，不同的神经元状态相互作用，以支持连续试验中WM表征的维持和检索。简单的工作记忆任务显示额叶和顶叶皮层持续的神经放电。在这里，作者展示了目标沉默和重新激活的周期，这些周期更局限于顶叶而不是额叶皮层中的单个目标。
While classic views proposed that working memory (WM) is mediated by sustained firing, recent evidence suggests a contribution of activity-silent states. Within WM, human neuroimaging studies suggest a switch between attentional foreground and background, with only the foregrounded item represented in active neural firing. To address this process at the cellular level, we recorded prefrontal (PFC) and posterior parietal (PPC) neurons in a complex problem-solving task, with monkeys searching for one or two target locations in a first cycle of trials, and retaining them for memory-guided revisits on subsequent cycles. When target locations were discovered, neither frontal nor parietal neurons showed sustained goal-location codes continuing into subsequent trials and cycles. Instead there were sequences of timely goal silencing and reactivation, and following reactivation, sustained states until behavioral response. With two target locations, goal representations in both regions showed evidence of transitions between foreground and background, but the PFC representation was more complete, extending beyond the current trial to include both past and future selections. In the absence of unbroken sustained codes, different neuronal states interact to support maintenance and retrieval of WM representations across successive trials. Simple working memory tasks show sustained neural firing in frontal and parietal cortex. Here, the authors show cycles of target silencing and reactivation that are more restricted to single targets in parietal than frontal cortex.
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影响因子：
3
作者：
Drucker CB;Carlson ML;Toda K;DeWind NK;Platt ML
通讯作者：
Platt ML
影响因子：
3.4
作者：
Bhandari A;Duncan J
通讯作者：
Duncan J
影响因子：
3.7
作者：
LaRocque, Joshua J.;Riggall, Adam C.;Postle, Bradley R.
通讯作者：
Postle, Bradley R.
影响因子：
56.9
作者：
FUSTER, JM;ALEXANDER, GE
通讯作者：
ALEXANDER, GE
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y