Identifying the neural correlates of anticipatory postural control: A novel fMRI paradigm.
Identifying the neural correlates of anticipatory postural control: A novel fMRI paradigm.
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DOI：
10.1002/hbm.26332
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发表时间：
2023-07
影响因子：
4.8
通讯作者：
Cramer, Steven C.
中科院分区：
文献类型：
--
作者：
Smith, Jo Armour;Tain, Rongwen;Sharp, Kelli G.;Glynn, Laura M.;Van Dillen, Linda R.;Henslee, Korinne;Jacobs, Jesse V.;Cramer, Steven C.
躯干/臀部肌肉系统的姿势控制改变是多种神经和肌肉骨骼疾病的特征。以前，它是不可能的，以确定是否改变皮层和皮层下感觉运动脑激活的基础损害的姿势控制。这项研究使用了一种新的功能磁共振成像兼容的范例，以确定与躯干和臀部肌肉组织的姿势控制相关的大脑激活。BOLD fMRI成像是在参与者执行两种版本的下肢任务时进行的，其中包括抬起左腿以将脚接触到目标。对于支撑式抬腿（SLR），腿从膝盖抬起，而大腿保持支撑。对于无支撑抬腿（ULR），腿从臀部抬起，需要腹部/臀部伸肌肌肉系统中的姿势肌肉激活。在SLR任务中，显著的大脑激活主要发生在右侧初级和次级感觉运动皮层区域。在ULR任务期间，大脑激活发生在初级和次级感觉运动皮层区域以及小脑和壳核的双侧。与SLR相比，ULR与右侧运动前区/SMA、左侧初级运动和扣带皮层、初级体感皮层、缘上回/顶叶盖、上级顶叶小叶、小脑蚓部和小脑半球的显著更大激活相关。皮质和皮质下区域在ULR期间激活，但在SLR期间没有激活，这与涉及多节段、双侧姿势控制的任务的规划和执行一致。未来的研究将使用这种模式，以确定潜在的机制受损的姿势控制神经和肌肉骨骼功能障碍的患者。在神经和肌肉骨骼功能障碍的患者人群中，躯干/髋关节肌肉组织的姿势控制受损。确定这种损伤的神经相关性一直是一个挑战。在这里，我们描述了一种新的功能性MRI任务，使躯干/髋关节姿势控制的量化，我们确定了健康成人的姿势控制相关的皮质和皮质下区域。
Altered postural control in the trunk/hip musculature is a characteristic of multiple neurological and musculoskeletal conditions. Previously it was not possible to determine if altered cortical and subcortical sensorimotor brain activation underlies impairments in postural control. This study used a novel fMRI‐compatible paradigm to identify the brain activation associated with postural control in the trunk and hip musculature. BOLD fMRI imaging was conducted as participants performed two versions of a lower limb task involving lifting the left leg to touch the foot to a target. For the supported leg raise (SLR) the leg is raised from the knee while the thigh remains supported. For the unsupported leg raise (ULR) the leg is raised from the hip, requiring postural muscle activation in the abdominal/hip extensor musculature. Significant brain activation during the SLR task occurred predominantly in the right primary and secondary sensorimotor cortical regions. Brain activation during the ULR task occurred bilaterally in the primary and secondary sensorimotor cortical regions, as well as cerebellum and putamen. In comparison with the SLR, the ULR was associated with significantly greater activation in the right premotor/SMA, left primary motor and cingulate cortices, primary somatosensory cortex, supramarginal gyrus/parietal operculum, superior parietal lobule, cerebellar vermis, and cerebellar hemispheres. Cortical and subcortical regions activated during the ULR, but not during the SLR, were consistent with the planning, and execution of a task involving multisegmental, bilateral postural control. Future studies using this paradigm will determine mechanisms underlying impaired postural control in patients with neurological and musculoskeletal dysfunction. Postural control in the trunk/hip musculature is impaired in patient populations with neurological and musculoskeletal dysfunction. It has been challenging to determine the neural correlates of this impairment. Here we describe a novel functional MRI task that enables quantification of trunk/hip postural control, and we identify cortical and subcortical regions associated with postural control in healthy adults.
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影响因子：
5.5
作者：
Chiou, Shin-Yi;Hurry, Madeleine;Strutton, Paul H.
通讯作者：
Strutton, Paul H.
影响因子：
3.4
作者：
Jacobs JV;Henry SM;Horak FB
通讯作者：
Horak FB
影响因子：
2.1
作者：
Bigongiari, Aline;de Andrade e Souza, Flavia;Mochizuki, Luis
通讯作者：
Mochizuki, Luis
影响因子：
4.8
作者：
Casado-Aranda, Luis-Alberto;Van der Laan, Laura Nynke;Sanchez-Fernandez, Juan
通讯作者：
Sanchez-Fernandez, Juan
DOI：
10.1016/j.spinee.2014.10.020
发表时间：
2015-04-01
期刊：
The spine journal : official journal of the North American Spine Society
影响因子：
--
作者：
Lomond KV;Jacobs JV;Hitt JR;DeSarno MJ;Bunn JY;Henry SM
通讯作者：
Henry SM