A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility.
A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility.
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DOI：
10.1155/2016/2960372
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Liu H;Zeng L;Yang K;Zhang G
瞄准从网络药理学角度探讨逍遥散治疗无排卵性不孕症的药理机制。法通过中药数据库收集XYP的活性成分，并将其输入PharmMapper，得到其靶点。然后通过京都基因和基因组百科全书（KEGG）对这些靶点进行注释，并筛选出可被人类信号通路所注释的靶点。通过数据库获取有效成分的现代药理学信息和方剂的传统功效。通过治疗靶点数据库（TTD）获取不孕症靶点。通过String和INACT收集所有靶标与其他人类蛋白质的相互作用。将所有目标放入数据库中进行注释，可视化和集成发现（大卫），以进行GO富集分析。最后，根据以上信息，用Cytoscape绘制网络。结果.可视化了六张网络图和两张GO富集分析图。结论根据这一网络药理学途径，首次发现了XYP作用于不孕症的某些信号通路。一些生物学过程也可以被确定为XYP对无排卵性不孕症的影响。我们认为，从系统水平上评价中药方剂的功效，揭示其药理作用机制，将是今后研究的重要方法。
Aim. To explore the pharmacological mechanism of Xiaoyao powder (XYP) on anovulatory infertility by a network pharmacology approach. Method. Collect XYP's active compounds by traditional Chinese medicine (TCM) databases, and input them into PharmMapper to get their targets. Then note these targets by Kyoto Encyclopedia of Genes and Genomes (KEGG) and filter out targets that can be noted by human signal pathway. Get the information of modern pharmacology of active compounds and recipe's traditional effects through databases. Acquire infertility targets by Therapeutic Target Database (TTD). Collect the interactions of all the targets and other human proteins via String and INACT. Put all the targets into the Database for Annotation, Visualization, and Integrated Discovery (DAVID) to do GO enrichment analysis. Finally, draw the network by Cytoscape by the information above. Result. Six network pictures and two GO enrichment analysis pictures are visualized. Conclusion. According to this network pharmacology approach some signal pathways of XYP acting on infertility are found for the first time. Some biological processes can also be identified as XYP's effects on anovulatory infertility. We believe that evaluating the efficacy of TCM recipes and uncovering the pharmacological mechanism on a systematic level will be a significant method for future studies.
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