Altered neural oscillations during complex sequential movements in patients with Parkinson's disease.
Altered neural oscillations during complex sequential movements in patients with Parkinson's disease.
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DOI：
10.1016/j.nicl.2021.102892
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
McCusker MC;Wiesman AI;Spooner RK;Santamaria PM;McKune J;Heinrichs-Graham E;Wilson TW
帕金森病（PD）中服务于简单和复杂运动表现的神经动力学尚未被了解。
帕金森病患者和健康成年人在脑磁图（MEG）检测期间进行简单和复杂的手指敲击序列动作。
与健康成年人相比，帕金森病患者完成一组连续动作的速度较慢。
帕金森病患者在顶叶后下部小叶呈现出较弱的与复杂性相关的α振荡模式。
帕金森病（PD）的后遗症包括运动相关和认知相关的症状。尽管传统上被认为是一种皮质下疾病，但越来越多的证据表明帕金森病对皮质功能也有重大影响。先前的研究已经报道了帕金森病患者在运动期间皮质神经功能的改变，但到目前为止，这些研究尚未检验多成分运动的复杂性是否会调节这些改变。在这项研究中，23名帕金森病患者（处于停药状态）和27名匹配的健康对照者在脑磁图（MEG）检测期间进行简单和复杂的手指敲击序列动作，并且对所得的MEG数据进行成像以识别服务于运动表现的皮质振荡动力学。总体而言，帕金森病患者在执行序列动作时明显比对照者慢，并且两组完成复杂序列动作都比完成简单序列动作花费更长时间。在神经差异方面，患者在右侧内侧额叶回还表现出较弱的与β复杂性相关的效应，在右侧顶叶后下部小叶表现出较弱的与复杂性相关的α活动，这表明运动序列执行受损。对帕金森病皮质病理生理学的特征描述可以为当前和未来针对运动和认知症状的治疗干预提供信息。
The neural dynamics serving the performance of simple and complex movements in Parkinson’s disease (PD) are not understood. Patients with PD and healthy adults performed simple and complex finger tapping sequences during MEG. Patients with PD were slower to complete a set of sequential movements compared to healthy adults. Patients with PD exhibited weaker complexity-related alpha oscillatory patterns in the posterior and inferior parietal lobules. The sequelae of Parkinson’s disease (PD) includes both motor- and cognitive-related symptoms. Although traditionally considered a subcortical disease, there is increasing evidence that PD has a major impact on cortical function as well. Prior studies have reported alterations in cortical neural function in patients with PD during movement, but to date such studies have not examined whether the complexity of multicomponent movements modulate these alterations. In this study, 23 patients with PD (medication “off” state) and 27 matched healthy controls performed simple and complex finger tapping sequences during magnetoencephalography (MEG), and the resulting MEG data were imaged to identify the cortical oscillatory dynamics serving motor performance. The patients with PD were significantly slower than controls at executing the sequences overall, and both groups took longer to complete the complex sequences than the simple. In terms of neural differences, patients also exhibited weaker beta complexity-related effects in the right medial frontal gyrus and weaker complexity-related alpha activity in the right posterior and inferior parietal lobules, suggesting impaired motor sequence execution. Characterizing the cortical pathophysiology of PD could inform current and future therapeutic interventions that address both motor and cognitive symptoms.
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DOI：
10.1016/j.nicl.2017.02.010
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Heinrichs-Graham E;Santamaria PM;Gendelman HE;Wilson TW
通讯作者：
Wilson TW
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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