3D multislab, multishot acquisition for fast, whole-brain MR elastography with high signal-to-noise efficiency.
3D multislab, multishot acquisition for fast, whole-brain MR elastography with high signal-to-noise efficiency.
复制标题
DOI：
10.1002/mrm.25065
复制
发表时间：
2014-02
影响因子：
3.3
通讯作者：
Sutton, Bradley P.
中科院分区：
文献类型：
--
作者：
Johnson, Curtis L.;Holtrop, Joseph L.;McGarry, Matthew D. J.;Weaver, John B.;Paulsen, Keith D.;Georgiadis, John G.;Sutton, Bradley P.
开发一种采集方案，用于在短扫描时间内生成具有全脑覆盖、高空间分辨率和足够信噪比（SNR）的磁共振弹性成像（MRE）位移数据。提出了一种全脑磁共振成像的三维多实验室、多激发采集方法，空间分辨率为2.0 mm。多实验室方法允许使用短重复时间来实现非常高的SNR效率。高SNR效率使得采集时间仅减少6分钟，同时保持反演所需的最低SNR。从全脑位移数据与非线性反演（NLI）估计的力学特性图表现出良好的协议与神经解剖学特征，包括小脑和脑干。与等效2D采集的比较说明了3D多实验室采集的SNR效率的提高。高SNR效率提供的灵活性允许使用1.6 mm各向同性体素尺寸实现更高的分辨率，与2.0 mm各向同性采集相比，这产生了更高的脑干硬度估计值。所提出的采集允许在短扫描时间内捕获全脑MRE位移数据，并且可以用于生成整个大脑的神经解剖特征的局部机械特性估计。
To develop an acquisition scheme for generating magnetic resonance elastography (MRE) displacement data with whole-brain coverage, high spatial resolution, and adequate signal-to-noise ratio (SNR) in a short scan time. A 3D multislab, multishot acquisition for whole-brain MRE with 2.0 mm isotropic spatial resolution is proposed. The multislab approach allowed for the use of short repetition time to achieve very high SNR efficiency. High SNR efficiency allowed for a reduced acquisition time of only six minutes while the minimum SNR needed for inversion was maintained. The mechanical property maps estimated from whole-brain displacement data with nonlinear inversion (NLI) demonstrated excellent agreement with neuroanatomical features, including the cerebellum and brainstem. A comparison with an equivalent 2D acquisition illustrated the improvement in SNR efficiency of the 3D multislab acquisition. The flexibility afforded by the high SNR efficiency allowed for higher resolution with a 1.6 mm isotropic voxel size, which generated higher estimates of brainstem stiffness compared with the 2.0 mm isotropic acquisition. The acquisition presented allows for the capture of whole-brain MRE displacement data in a short scan time, and may be used to generate local mechanical property estimates of neuroanatomical features throughout the brain.
登录
查看更多内容
通过磁共振弹性成像确定阿尔茨海默氏病的大脑硬度降低。
影响因子：
4.4
作者：
Murphy, Matthew C.;Huston, John, III;Jack, Clifford R., Jr.;Glaser, Kevin J.;Manduca, Armando;Felmlee, Joel P.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
2.4
作者：
Arbogast, KB;Margulies, SS
通讯作者：
Margulies, SS
影响因子：
2.4
作者：
Arbogast, KB;Margulies, SS
通讯作者：
Margulies, SS
影响因子：
3.5
作者：
McGarry MD;Van Houten EE;Perriñez PR;Pattison AJ;Weaver JB;Paulsen KD
通讯作者：
Paulsen KD
朝向大脑解剖结构的弹性图。
影响因子：
3.7
作者：
Guo J;Hirsch S;Fehlner A;Papazoglou S;Scheel M;Braun J;Sack I
通讯作者：
Sack I