Fetal microchimerism and maternal health during and after pregnancy
Fetal microchimerism and maternal health during and after pregnancy
复制标题
胎儿微嵌合现象与怀孕期间和怀孕后的母亲健康
作者：
K. O'Donoghue
Trafficking of fetal cells into the maternal circulation begins very early in pregnancy and the effects of this cell traffic are longlasting. All types of fetal cells, including stem cells, cross the placenta during normal pregnancy to enter maternal blood, from where they may be recovered in pregnancy for the purpose of genetic prenatal diagnosis. Fetal cells can also be located in maternal tissues during and after pregnancy, and persist as microchimeric cells for decades in marrow and other organs. Although persistent fetal cells were first implicated in autoimmune disease, subsequent reports routinely found microchimeric cells in healthy tissues and in non-autoimmune disease. Parallel studies in animal and human pregnancy now suggest instead that microchimeric fetal cells play a role in the response to tissue injury. However, it is still not clear whether microchimeric fetal cells persisting in the mother are an incidental finding, are naturally pathogenic or act as reparative stem cells, and the environmental or biological stimuli that determine microchimeric cell fate are as yet undetermined. Future studies must also focus on investigating whether fetal cells create functional improvement in response to maternal injury and whether this response can be manipulated. The pregnancy-acquired low-grade chimeric state of women could have far-reaching implications, influencing recovery after injury or surgery, ageing, graft survival after transplantation, survival after cancer as well as deciding the protective effect of pregnancy against diseases later in life. Lifelong persistence of fetal cells in maternal tissues may even explain why women live longer than men.
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影响因子：
4.8
作者：
M. Imaizumi;A. Pritsker;P. Unger;T. Davies
通讯作者：
M. Imaizumi;A. Pritsker;P. Unger;T. Davies
格雷夫斯病中的甲状腺内胎儿微嵌合现象。
DOI：
10.1210/jcem.87.7.8656
发表时间：
2002
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Ando,Takao;Imaizumi,Misa;Graves,PeterN;Unger,Pamela;Davies,TerryF
通讯作者：
Davies,TerryF
妊娠、微嵌合现象和自身免疫性疾病的 HLA 关系。
影响因子：
3.4
作者：
J. Nelson
通讯作者：
J. Nelson
人类自然嵌合现象：后天的性格还是进化的痕迹？
影响因子：
2.7
作者：
Rinkevich,B
通讯作者：
Rinkevich,B
影响因子：
13.6
作者：
Lambert, N;Nelson, JL
通讯作者：
Nelson, JL