Pharmacokinetic disposition of sulfadoxine in children with acute uncomplicated falciparum malaria treated with sulfadoxine-pyrimethamine in South West Nigeria.
Pharmacokinetic disposition of sulfadoxine in children with acute uncomplicated falciparum malaria treated with sulfadoxine-pyrimethamine in South West Nigeria.
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尼日利亚西南部接受磺胺多辛-乙胺嘧啶治疗的急性无并发症恶性疟疾儿童中磺胺多辛的药代动力学分布。
DOI：
10.1097/mjt.0b013e3181baf266
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发表时间：
2012
影响因子：
4.2
通讯作者：
Oduola,Ayoade
中科院分区：
文献类型：
--
作者：
Gbotosho,GraceOlusola;Happi,ChristianTientcha;Sijuade,Abayomi;Sowunmi,Akin;Oduola,Ayoade
磺胺多辛-乙胺嘧啶目前被推荐作为疟疾化疗中青蒿琥酯的辅助用药。然而，关于sdx -乙胺嘧啶在儿童中的药代动力学处置的信息是有限的。因此，本研究致力于利用高压液相色谱技术评估SDX的药代动力学配置，以及药代动力学变异性对尼日利亚恶性疟疾儿童治疗结果的影响。在感染对治疗有反应的患者和治疗失败的患者中，SDX的血药浓度谱相似；SDX的平均浓度在第3天（179 vs 157 μg/mL， P= 0.734）、第7天（84 vs 51 μg/mL， P= 0.365）和第14天（50 vs 14 μg/mL， P= 0.151）相似。患者对SDX的暴露程度（曲线下面积）也相似（1196 vs 1013 μg d/mL， P= 0.561）。Pearson相关分析显示，曲线下面积与SDX的D3或D7浓度有显著相关性（P= 0.001, r= 0.702或P= 0.001, r= 0.835）。年龄分层分析显示，年龄较大的儿童（大于5岁）SDX浓度显著较高；平均最大浓度（125 vs 295 μg/mL， P= 0.001）、暴露程度（812 vs 1562 μg d/mL， P= 0.001）、第3天浓度（98 vs 250 μg/mL， P= 0.001）和第7天浓度（54 vs 128 μg/mL， P= 0.007）较高。该研究显示，对治疗有反应的患者和对治疗无反应的患者在治疗后血液中SDX浓度没有差异。此外，在所研究的儿童组中，SDX存在与年龄相关的药代动力学变异性，这可能对治疗结果产生影响。
Sulfadoxine (SDX)–pyrimethamine is currently recommended as a partner drug with artesunate in the chemotherapy of malaria. However, information on pharmacokinetic disposition of SDX–pyrimethamine in children is limited. Efforts in this study were thus devoted to evaluation of pharmacokinetic disposition of SDX using high-pressure liquid chromatographic techniques and effects of pharmacokinetic variability on treatment outcome in Nigerian children with falciparum malaria. The blood concentration profile of SDX was similar in patients whose infection responded to treatment and those who failed treatment; mean SDX concentration values were similar for day 3 (179 vs 157 μg/mL, P= 0.734), day 7 (84 vs 51 μg/mL, P= 0.365), and day 14 (50 vs 14 μg/mL, P= 0.151). Extent of exposure (area under the curve) to SDX was also similar in the patients (1196 vs 1013 μg d/mL, P= 0.561). Pearson's correlation, showed significant correlation between area under the curve and D3 or D7 concentration of SDX (P= 0.001, r= 0.702 or P= 0.001, r= 0.835, respectively). Age-stratified analysis showed that SDX concentrations were significantly higher in older children (older than 5 years); the mean maximum concentration (125 vs 295 μg/mL, P= 0.001), extent of exposure (812 vs 1562 μg d/mL, P= 0.001), day 3 concentration (98 vs 250 μg/mL, P= 0.001), and day 7 concentration (54 vs 128 μg/mL, P= 0.007) were higher. The study revealed no differences in posttreatment blood SDX concentrations in patients who responded to treatment and those who failed to respond to treatment. Furthermore, there was an age-related pharmacokinetic variability of SDX in the group of children studied with potential impact on treatment outcome.
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影响因子：
6.2
作者：
Anisimov, Vladimir N.;Bartke, Andrzej
通讯作者：
Bartke, Andrzej
使用依维莫司 (RAD001) 和阿仑单抗治疗复发/难治性慢性淋巴细胞白血病/小淋巴细胞淋巴瘤：一项 I/II 期研究
影响因子：
2.6
作者：
C. Zent;D. Bowen;Michael J. Conte;B. Laplant;T. Call
通讯作者：
T. Call
影响因子：
6
作者：
Allen, Larry A.;Felker, G. Michael;Mehra, Mandeep R.;Chiong, Jun R.;Dunlap, Stephanie H.;Ghali, Jalal K.;Lenihan, Daniel J.;Oren, Ron M.;Wagoner, Lynne E.;Schwartz, Todd A.;Adams, Kirkwood F., Jr.
通讯作者：
Adams, Kirkwood F., Jr.
影响因子：
20.3
作者：
Oscier, DG;Thompsett, A;Stevenson, FK
通讯作者：
Stevenson, FK
影响因子：
16.8
作者：
Burger JA;Chiorazzi N
通讯作者：
Chiorazzi N