NCBI GEO: archive for high-throughput functional genomic data.
NCBI GEO: archive for high-throughput functional genomic data.
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DOI:
10.1093/nar/gkn764
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发表时间:
2009-01
影响因子:
14.9
通讯作者:
Edgar R
中科院分区:
文献类型:
--
作者:
Barrett T;Troup DB;Wilhite SE;Ledoux P;Rudnev D;Evangelista C;Kim IF;Soboleva A;Tomashevsky M;Marshall KA;Phillippy KH;Sherman PM;Muertter RN;Edgar R
The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) is the largest public repository for high-throughput gene expression data. Additionally, GEO hosts other categories of high-throughput functional genomic data, including those that examine genome copy number variations, chromatin structure, methylation status and transcription factor binding. These data are generated by the research community using high-throughput technologies like microarrays and, more recently, next-generation sequencing. The database has a flexible infrastructure that can capture fully annotated raw and processed data, enabling compliance with major community-derived scientific reporting standards such as ‘Minimum Information About a Microarray Experiment’ (MIAME). In addition to serving as a centralized data storage hub, GEO offers many tools and features that allow users to effectively explore, analyze and download expression data from both gene-centric and experiment-centric perspectives. This article summarizes the GEO repository structure, content and operating procedures, as well as recently introduced data mining features. GEO is freely accessible at http://www.ncbi.nlm.nih.gov/geo/.
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影响因子:
14.9
作者:
Barrett, Tanya;Troup, Dennis B.;Wilhite, Stephen E.;Ledoux, Pierre;Rudnev, Dmitry;Evangelista, Carlos;Kim, Irene F.;Soboleva, Alexandra;Tomashevsky, Maxim;Edgar, Ron
通讯作者:
Edgar, Ron
影响因子:
14.9
作者:
Wheeler, David L.;Barrett, Tanya;Benson, Dennis A.;Bryant, Stephen H.;Canese, Kathi;Chetvernin, Vyacheslav;Church, Deanna M.;DiCuccio, Michael;Edgar, Ron;Federhen, Scott;Feolo, Michael;Geer, Lewis Y.;Helmberg, Wolfgang;Kapustin, Yuri;Khovayko, Oleg;Landsman, David;Lipman, David J.;Madden, Thomas L.;Maglott, Donna R.;Miller, Vadim;Ostell, James;Pruitt, Kim D.;Schuler, Gregory D.;Shumway, Martin;Sequeira, Edwin;Sherry, Steven T.;Sirotkin, Karl;Souvorov, Alexandre;Starchenko, Grigory;Tatusov, Roman L.;Tatusova, Tatiana A.;Wagner, Lukas;Yaschenko, Eugene
通讯作者:
Yaschenko, Eugene
影响因子:
14.9
作者:
Edgar, R;Domrachev, M;Lash, AE
通讯作者:
Lash, AE
影响因子:
64.8
作者:
Meissner, Alexander;Mikkelsen, Tarjei S.;Gu, Hongcang;Wernig, Marius;Hanna, Jacob;Sivachenko, Andrey;Zhang, Xiaolan;Bernstein, Bradley E.;Nusbaum, Chad;Jaffe, David B.;Gnirke, Andreas;Jaenisch, Rudolf;Lander, Eric S.
通讯作者:
Lander, Eric S.
影响因子:
5.8
作者:
Sean, Davis;Meltzer, Paul S.
通讯作者:
Meltzer, Paul S.