The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.
The HMG-CoA reductase gene and lipid and lipoprotein levels: the multi-ethnic study of atherosclerosis.
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DOI：
10.1007/s11745-009-3314-6
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发表时间：
2009-08
期刊：
影响因子：
1.9
通讯作者：
Taylor, Kent D.
中科院分区：
文献类型：
--
作者：
Chen, Yi-Chun;Chen, Yii-Der I.;Li, Xiaohui;Post, Wendy;Herrington, David;Polak, Joseph F.;Rotter, Jerome I.;Taylor, Kent D.
关键词：
HMG-CoA还原酶（HMGCR）是一种参与胆固醇合成的酶。为了研究HMGCR基因在不同种族中对脂质和脂蛋白亚组分的贡献，我们在多种族动脉粥样硬化研究（梅萨）中进行了关联研究。共纳入2444例未使用他汀类药物的梅萨受试者（597例非洲裔美国人（AA）、627例华裔美国人（CHA）、612例欧洲裔美国人（EA）和608例西班牙裔美国人（HA））。参与者测量血压，人体测量和空腹血液样本。受试者进行了10个单核苷酸多态性（SNP）的基因分型。在排除次要等位基因频率<5%的SNP后，构建单个区块。除AA（H2 a，44.9%）外，所有种族中最常见的单倍型为H1（41-56%）。较低的甘油三酯水平与AA中的H2 a单倍型和HA中的H2单倍型相关。在HA中，H4携带者具有较高水平的甘油三酯和小低密度脂蛋白（s-LDL），以及较低的高密度脂蛋白胆固醇（HDL-c），而H7或H8携带者与这些性状的相关性相反。在CHA和EA中未发现显著关联。在HA和AA中，可单独由H2解释的甘油三酯总变异分别为2.6%和1.4%。总之，HMGCR基因变异与多种脂质/脂蛋白性状相关，尤其是与甘油三酯、s-LDL和HDL-c相关。遗传变异的影响是适度的，种族之间差异很大。
HMG-CoA reductase (HMGCR) is an enzyme involved in cholesterol synthesis. To investigate the contribution of the HMGCR gene to lipids and lipoprotein subfraction in different ethnicities, we performed an association study in the Multi-Ethnic Study of Atherosclerosis (MESA). Totally, 2444 MESA subjects (597 African-Americans (AA), 627 Chinese-Americans (CHA), 612 European-Americans (EA), and 608 Hispanic-Americans (HA)) without statin use were included. Participants had measurements of blood pressure, anthropometry, and fasting blood samples. Subjects were genotyped for 10 single nucleotide polymorphisms (SNPs). After excluding SNPs with minor allele frequency <5%, a single block was constructed. The most frequent haplotype was H1 (41-56%) in all ethnic groups except AA (H2a, 44.9%). Lower triglyceride level was associated with the H2a haplotype in AA and H2 in HA. In HA, H4 carriers had higher levels of triglyceride and small low-density lipoprotein (s-LDL), and lower high-density lipoprotein cholesterol (HDL-c), while carriers with H7 or H8 had associations with these traits in the opposite direction. No significant association was discovered in both CHA and EA. The total variation for triglyceride that could be explained by H2 alone was 2.6% in HA and 1.4% in AA. In conclusion, HMGCR gene variation is associated with multiple lipid/lipoprotein traits, especially with triglyceride, s-LDL, and HDL-c. The impact of the genetic variance is modest and differs greatly between ethnicities.
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与人类血液低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或甘油三酯相关的六个新位点。
影响因子：
30.8
作者：
Kathiresan, Sekar;Melander, Olle;Guiducci, Candace;Surti, Aarti;Burtt, Noel P.;Rieder, Mark J.;Cooper, Gregory M.;Roos, Charlotta;Voight, Benjamin F.;Havulinna, Aki S.;Wahlstrand, Bjorn;Hedner, Thomas;Corella, Dolores;Tai, E. Shyong;Ordovas, Jose M.;Berglund, Goran;Vartiainen, Erkki;Jousilahti, Pekka;Hedblad, Bo;Taskinen, Marja-Riitta;Newton-Cheh, Christopher;Salomaa, Veikko;Peltonen, Leena;Groop, Leif;Altshuler, David M.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
影响因子：
9.8
作者：
Duggirala, R;Blangero, D;Stern, MP
通讯作者：
Stern, MP
影响因子：
3.2
作者：
Hsiao, Chin-Fu;Chiu, Yen-Feng;Hsiung, Chao A.
通讯作者：
Hsiung, Chao A.
影响因子：
168.9
作者：
Anand, SS;Yusuf, S;McQueen, M
通讯作者：
McQueen, M
影响因子：
5
作者：
Bild, DE;Bluemke, DA;Tracy, RP
通讯作者：
Tracy, RP