Impact of endometriosis on obstetric outcome after natural conception: a multicenter Italian study.
Impact of endometriosis on obstetric outcome after natural conception: a multicenter Italian study.
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DOI：
10.1007/s00404-021-06243-z
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发表时间：
2022-01
影响因子：
2.6
通讯作者：
Endometriosis Treatment Italian Club (ETIC)
中科院分区：
文献类型：
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作者：
Berlanda N;Alio W;Angioni S;Bergamini V;Bonin C;Boracchi P;Candiani M;Centini G;D'Alterio MN;Del Forno S;Donati A;Dridi D;Incandela D;Lazzeri L;Maiorana A;Mattei A;Ottolina J;Orenti A;Perandini A;Perelli F;Piacenti I;Pino I;Porpora MG;Scaramuzzino S;Seracchioli R;Solima E;Somigliana E;Venturella R;Vercellini P;Viganò P;Vignali M;Zullo F;Zupi E;Endometriosis Treatment Italian Club (ETIC)
评价意大利自然受孕并接受标准产科护理的子宫内膜异位症妇女的产科结局。病例是在11个意大利转诊中心治疗的子宫内膜异位症连续妇女。对照组为排除子宫内膜异位症的妇女。所有妇女都填写了一份调查表，说明以前的自然怀孕情况。边缘逻辑回归模型拟合评估子宫内膜异位症对产科结局的影响。在子宫内膜异位症组中进行了一项事后分析，将重度子宫内膜异位症妇女与无或轻度子宫内膜异位症妇女进行比较。子宫内膜异位症组355例，对照组741例。子宫内膜异位症的妇女有较高的风险早产< 34周（6.4% vs 2.8%，OR 2.42，95% CI 1.22-4.82），早产< 37周（17.8% vs 9.7%，OR 1.98，95%CI 1.23-3.19）和新生儿入院重症监护室（14.1% vs 7.0%，OR 2.04，95%CI 1.23-3.36）。在事后分析中，患有子宫内膜异位症和严重子宫腺肌病的妇女发生前置胎盘的风险增加（23.1% vs 1.8%，OR 16.68，95%CI 3.49-79.71），剖宫产（84.6% vs 38.9%，OR 8.03，95% CI 1.69-38.25）和早产< 34周（23.1% vs 5.7%，OR 5.52，95% CI 1.38-22.09）。子宫内膜异位症妇女自然受孕早产和新生儿入住重症监护室的风险增加。当严重的子宫腺肌病合并子宫内膜异位症时，妇女前置胎盘和剖宫产的风险增加。临床试验注册号：NCT 03354793。
To evaluate obstetric outcome in women with endometriosis who conceive naturally and receive standard obstetric care in Italy. Cases were consecutive women with endometriosis managed in eleven Italian referral centers. Controls were women in whom endometriosis was excluded. All women filled in a questionnaire addressing previous natural pregnancies. Marginal logistic regression models were fitted to evaluate the impact of endometriosis on obstetric outcome. A post hoc analysis was performed within the endometriosis group comparing women with severe adenomyosis versus women with absent or mild adenomyosis. Three hundred and fifty-five pregnancies in endometriosis group and 741 pregnancies in control group were included. Women with endometriosis had a higher risk of preterm delivery < 34 weeks (6.4% vs 2.8%, OR 2.42, 95% CI 1.22–4.82), preterm delivery < 37 weeks (17.8% vs 9.7%, OR 1.98, 95% CI 1.23–3.19), and neonatal admission to Intensive Care Unit (14.1% vs 7.0%, OR 2.04, 95% CI 1.23–3.36). At post hoc analysis, women with endometriosis and severe adenomyosis had an increased risk of placenta previa (23.1% vs 1.8%, OR 16.68, 95% CI 3.49–79.71), cesarean delivery (84.6% vs 38.9%, OR 8.03, 95% CI 1.69–38.25) and preterm delivery < 34 weeks (23.1% vs 5.7%, OR 5.52, 95% CI 1.38–22.09). Women with endometriosis who conceive naturally have increased risk of preterm delivery and neonatal admission to intensive care unit. When severe adenomyosis is coexistent with endometriosis, women may be at increased risk of placenta previa and cesarean delivery. Clinical trial registration number: NCT03354793.
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DOI：
10.1093/humrep/dey269
发表时间：
2018-10-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
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影响因子：
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影响因子：
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DOI：
10.1016/j.ejogrb.2013.10.024
发表时间：
2014-01-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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作者：
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