Applications of aptamers in targeted imaging: state of the art.
Applications of aptamers in targeted imaging: state of the art.
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DOI：
10.2174/1568026615666150413153400
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发表时间：
2015
影响因子：
3.4
通讯作者：
Hong H
中科院分区：
文献类型：
--
作者：
Dougherty CA;Cai W;Hong H
Aptamers are single-stranded oligonucleotides with high affinity and specificity to the target molecules or cells, thus they can serve as an important category of molecular targeting ligand. Since their discove1y, aptamers have been rapidly translated into clinical practice. The strong target affinity/selectivity, cost-effectivity, chemical versatility and safety of aptamers are superior to traditional peptides- or proteins-based ligands which make them unique choices for molecular imaging. Therefore, aptamers are considered to be extremely useful to guide various imaging contrast agents to the target tissues or cells for optical, magnetic resonance, nuclear, computed tomography, ultra sound and multimodality imaging. This review aims to provide an overview of aptamers' advantages as targeting ligands and their application in targeted imaging. Further research in synthesis of new types of aptamers and their conjugation with new categories of contrast agents is required to develop clinically translatable aptamer-based imaging agents which will eventually result in improved patient care.
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影响因子：
12.4
作者：
Chakravarty R;Goel S;Cai W
通讯作者：
Cai W
影响因子：
3.1
作者：
Da Pieve, Chiara;Perkins, Alan C.;Missailidis, Sotiris
通讯作者：
Missailidis, Sotiris
DOI：
10.1046/j.1432-1327.2000.01557.x
发表时间：
2000-08-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Andreola, ML;Calmels, C;Litvak, S
通讯作者：
Litvak, S
影响因子：
--
作者：
Charlton, J;Sennello, J;Smith, D
通讯作者：
Smith, D
DOI：
10.1002/wnan.1285
发表时间：
2015-01
影响因子：
8.6
作者：
Goodwin, Andrew P.;Nakatsuka, Matthew A.;Mattrey, Robert F.
通讯作者：
Mattrey, Robert F.