Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives.
Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives.
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DOI：
10.3390/v13030366
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发表时间：
2021-02-25
期刊：
影响因子：
--
通讯作者：
Amorim MJ
中科院分区：
文献类型：
--
作者：
Etibor TA;Yamauchi Y;Amorim MJ
病毒高度依赖于它们感染的宿主。它们的依赖触发了病毒-宿主共同适应的过程，使病毒能够在探索宿主资源的同时逃避免疫。科学家们在不同的复杂程度上解决了病毒与宿主之间的相互作用--在单个宿主、器官、组织和细胞中--并且开创性的研究促进了我们对病毒生命周期、物种内或物种间传播以及控制感染的手段的理解。最近，解决生物系统中材料的物理性质变得非常重要；膜结合的细胞器只是将分子从细胞环境中分离出来的众多方法之一。通过实现一种被称为生物分子凝聚体的缺乏膜的隔室，生物系统开发了另一种控制反应的机制。许多生物冷凝物表现出液体性质，这一发现导致了液液相分离(LLP)驱动其形成的提议。有限合伙人的概念是细胞结构和组织的范式转变。重新审视病毒学中长期存在的问题和探索新的抗病毒策略的势头前所未有。在本综述的第一部分中，我们重点介绍了生物分子缩合物的最新研究进展。在第二部分中，我们介绍了关于RNA病毒阶段生物学的已知知识，并讨论了这一新兴领域在病毒学中的未来前景。
Viruses are highly dependent on the host they infect. Their dependence triggers processes of virus–host co-adaptation, enabling viruses to explore host resources whilst escaping immunity. Scientists have tackled viral–host interplay at differing levels of complexity—in individual hosts, organs, tissues and cells—and seminal studies advanced our understanding about viral lifecycles, intra- or inter-species transmission, and means to control infections. Recently, it emerged as important to address the physical properties of the materials in biological systems; membrane-bound organelles are only one of many ways to separate molecules from the cellular milieu. By achieving a type of compartmentalization lacking membranes known as biomolecular condensates, biological systems developed alternative mechanisms of controlling reactions. The identification that many biological condensates display liquid properties led to the proposal that liquid–liquid phase separation (LLPS) drives their formation. The concept of LLPS is a paradigm shift in cellular structure and organization. There is an unprecedented momentum to revisit long-standing questions in virology and to explore novel antiviral strategies. In the first part of this review, we focus on the state-of-the-art about biomolecular condensates. In the second part, we capture what is known about RNA virus-phase biology and discuss future perspectives of this emerging field in virology.
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影响因子：
6.7
作者：
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Digard, Paul
DOI：
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发表时间：
1976-01-01
影响因子：
11.1
作者：
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通讯作者：
BANERJEE, AK
DOI：
10.1073/pnas.1509317112
发表时间：
2015-09-22
影响因子：
11.1
作者：
Berry, Joel;Weber, Stephanie C.;Brangwynne, Clifford P.
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Brangwynne, Clifford P.
影响因子：
64.5
作者：
Boija A;Klein IA;Sabari BR;Dall'Agnese A;Coffey EL;Zamudio AV;Li CH;Shrinivas K;Manteiga JC;Hannett NM;Abraham BJ;Afeyan LK;Guo YE;Rimel JK;Fant CB;Schuijers J;Lee TI;Taatjes DJ;Young RA
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Young RA