Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity.
Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity.
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DOI：
10.1371/journal.pone.0129513
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Chin K
中科院分区：
文献类型：
--
作者：
Toyama Y;Tanizawa K;Kubo T;Chihara Y;Harada Y;Murase K;Azuma M;Hamada S;Hitomi T;Handa T;Oga T;Chiba T;Mishima M;Chin K
阻塞性睡眠呼吸暂停（OSA）和肝脏脂肪堆积之间的关系经常被研究，因为这两种疾病都很常见。据报道，内脏脂肪与OSA和肝脏脂肪积累密切相关。近年来，阻塞性睡眠呼吸暂停与死亡率之间的性别差异引起了人们的广泛关注。目的：探讨阻塞性睡眠呼吸暂停、肝脏脂肪积累（计算机断层扫描）和内脏脂肪面积之间的关系及其性别差异。研究对象为188名男性和62名女性，他们连续接受了多导睡眠图和计算机断层扫描。在多变量分析中，尽管呼吸暂停低通气指数与总体男性的肝脏脂肪积累呈正相关，但osa相关因素均未与总体男性或女性参与者的肝脏脂肪积累独立相关。当使用日本肥胖或内脏肥胖（体重指数(BMI)≥25 kg/m2或内脏脂肪面积≥100 cm2）的特定定义进行亚组分析时，只有在没有内脏肥胖的男性中，除BMI、胰岛素抵抗和血清甘油三酯值外，氧饱和度<90%的睡眠时间百分比与肝脏脂肪积累独立相关（R2 = 15.1%， P<0.001）。在男性中，无论内脏脂肪面积大小，血氧饱和度<90%的睡眠时间百分比也是丙氨酸转氨酶值的决定因素。相比之下，无论是否存在内脏性肥胖，OSA与女性肝脏脂肪积累或丙氨酸转氨酶值无关。阻塞性睡眠呼吸暂停对肝脏脂肪堆积的内脏脂肪依赖性影响存在性别差异。虽然其机制尚不清楚，而且可能存在民族差异，日本也有内脏肥胖的具体标准，但即使没有明显内脏脂肪堆积的患者，从防止肝脏脂肪堆积和肝功能障碍的角度来看，男性OSA患者的治疗可能是有利的。
Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) ≥25 kg/m2 or visceral fat area ≥100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation <90%, in addition to BMI, insulin resistance, and serum triglyceride values, was independently correlated with liver fat accumulation (R2 = 15.1%, P<0.001). In males, percent sleep time of oxygen saturation <90% was also a determining factor for alanine aminotransferase values regardless of visceral fat area. In contrast, OSA was not associated with liver fat accumulation or alanine aminotransferase values in females whether or not visceral obesity was absent. Sex differences in the visceral fat-dependent impact of OSA on liver fat accumulation existed. Although the mechanisms are not known and ethnic differences may exist in addition to the specific criteria of visceral obesity in Japan, the treatment of male patients with OSA might be favorable from the viewpoint of preventing liver fat accumulation and liver dysfunction even in patients without obvious visceral fat accumulation.
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影响因子：
2.9
作者：
Jouet, Pauline;Sabate, Jean-Marc;Coffin, Benoit
通讯作者：
Coffin, Benoit
影响因子：
3.3
作者：
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5.6
作者：
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影响因子：
37.8
作者：
Gottlieb DJ;Yenokyan G;Newman AB;O'Connor GT;Punjabi NM;Quan SF;Redline S;Resnick HE;Tong EK;Diener-West M;Shahar E
通讯作者：
Shahar E
影响因子：
10
作者：
Hoyos, Camilla M.;Killick, Roo;Liu, Peter Y.
通讯作者：
Liu, Peter Y.