The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma.
The Role of Marrow Microenvironment in the Growth and Development of Malignant Plasma Cells in Multiple Myeloma.
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DOI：
10.3390/ijms22094462
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发表时间：
2021-04-24
影响因子：
5.6
通讯作者：
Terpos E
中科院分区：
文献类型：
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作者：
Giannakoulas N;Ntanasis-Stathopoulos I;Terpos E
多发性骨髓瘤的新疗法的开发和有效性已经在大型临床试验中得到证实。然而，尽管治疗取得了重大进展，多发性骨髓瘤仍然是一种无法治愈的恶性肿瘤。越来越多的数据阐明了我们对恶性浆细胞的遗传背景以及骨髓微环境的作用的理解。目前，骨髓瘤细胞与微环境之间的相互作用被认为是多发性骨髓瘤发病机制中的关键。黏附分子、细胞因子和细胞外基质在转基因克隆浆细胞和基质细胞之间的相互作用中起着关键作用，导致骨髓瘤细胞的增殖、进展和生存。在这篇综述中，我们对骨髓微环境在多发性骨髓瘤恶性浆细胞生长和发展中的多方面作用进行了综述。
The development and effectiveness of novel therapies in multiple myeloma have been established in large clinical trials. However, multiple myeloma remains an incurable malignancy despite significant therapeutic advances. Accumulating data have elucidated our understanding of the genetic background of the malignant plasma cells along with the role of the bone marrow microenvironment. Currently, the interaction among myeloma cells and the components of the microenvironment are considered crucial in multiple myeloma pathogenesis. Adhesion molecules, cytokines and the extracellular matrix play a critical role in the interplay among genetically transformed clonal plasma cells and stromal cells, leading to the proliferation, progression and survival of myeloma cells. In this review, we provide an overview of the multifaceted role of the bone marrow microenvironment in the growth and development of malignant plasma cells in multiple myeloma.
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影响因子：
2.7
作者：
Bernal, Monica;Garrido, Pilar;Ruiz-Cabello, Francisco
通讯作者：
Ruiz-Cabello, Francisco
影响因子：
20.3
作者：
Chesi, M;Brents, LA;Bergsagel, PL
通讯作者：
Bergsagel, PL
影响因子：
20.3
作者：
Abe, M;Hiura, K;Matsumoto, T
通讯作者：
Matsumoto, T
影响因子：
20.3
作者：
Bergsagel, PL;Kuehl, WM;Shaughnessy, J
通讯作者：
Shaughnessy, J
影响因子：
--
作者：
Berardi S;Ria R;Reale A;De Luisi A;Catacchio I;Moschetta M;Vacca A
通讯作者：
Vacca A