Effects of Hydroxyethyl‐Starch‐Bound Deferoxamine on Ischemia/Reperfusion Injury in Chronic Nerve Compression
Effects of Hydroxyethyl‐Starch‐Bound Deferoxamine on Ischemia/Reperfusion Injury in Chronic Nerve Compression
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羟乙基淀粉结合的去铁胺对慢性神经受压缺血/再灌注损伤的影响
DOI：
10.1055/s-2007-1000211
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发表时间：
1998
影响因子：
2.1
通讯作者：
Kyle Bickel
中科院分区：
文献类型：
--
作者：
P. Marin;M. Im;J. Girotto;G. Borschel;Kyle Bickel
作者先前已经证明，在急性神经压迫释放时，用去铁胺(一种铁络合剂和抗氧化剂)预处理，可提供对缺血/再灌注(I/R)损伤的保护。在这项研究中，他们评估了在慢性压迫的周围神经松解时使用羟乙基淀粉结合去铁胺(HES-DFO)的治疗干预是否能保护神经免受I/R损伤。取雄性SD大鼠43只，体重325~350g，用硅胶管压迫坐骨神经8周。治疗组在减压时静脉注射HES-DFO(70 mg/kg)，对照组在相同的时间、程序和路线静脉注射等量的羟乙基淀粉。从受压部位的神经组织样本以及对侧非受压神经进行丙二醛(MDA)检测，丙二醛是I/R损伤的标志。对照组的丙二醛水平高达正常的5倍，并在21天内没有恢复正常。相比之下，HES-DFO组的丙二醛水平与正常水平没有统计学上的显著差异。结果证实，在手术减压慢性压迫神经之前，用HES-DFO预处理对I/R损伤有明显的保护作用。
The authors have demonstrated previously that pretreatment with deferoxamine, an iron chelator and antioxidant, at the time of release in acute nerve compression, provided protection against ischemia/reperfusion (I/R) injury. In the present study, they evaluated whether therapeutic intervention with hydroxyethyl-starch-bound deferoxamine (HES-DFO) at the time of release of the chronically-compressed peripheral nerve protects the nerve from I/R injury. The sciatic nerves of 43 male Sprague-Dawley rats, weighing 325 to 350 g, were subjected to 8 weeks of compression with Silastic tubing. The treatment group received intravenous HES-DFO (70 mg/kg) at the time of decompression, while the control group received an equal volume of intravenous hetastarch vehicle at the same time schedule and route. Nerve-tissue samples from the compression site, as well as contralateral noncompressed nerves, were assayed for malondialdehyde (MDA), a marker of I/R injury. The control group exhibited MDA levels up to five times normal, and did not return to normal for 21 days. In contrast, the HES-DFO group had MDA levels that were not statistically significantly different from normal levels. The results confirm that pretreatment with HES-DFO prior to the surgical decompression of chronically-compressed nerve provides marked protection against I/R injury.
金属离子在皮瓣缺血/再灌注损伤中的作用。
DOI：
10.1016/0022-4804(89)90221-7
发表时间：
1989
期刊：
The Journal of surgical research
影响因子：
--
作者：
Yoon,JO;Im,MJ;Manson,PN;Bulkley,GB;Hoopes,JE
通讯作者：
Hoopes,JE
影响因子：
19.6
作者：
PALLER, MS;HEDLUND, BE;WATERFIELD, R
通讯作者：
WATERFIELD, R