Liver abscess and bacteremia caused by lactobacillus: role of probiotics? Case report and review of the literature.

Liver abscess and bacteremia caused by lactobacillus: role of probiotics? Case report and review of the literature.
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DOI:
10.1186/s12876-016-0552-y
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发表时间:
2016-11-18
影响因子:
2.4
通讯作者:
Sridhar S
Sridhar S
中科院分区:
医学4区
文献类型:
--
作者:
Sherid M;Samo S;Sulaiman S;Husein H;Sifuentes H;Sridhar S

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乳杆菌是一种无芽胞、产乳酸、革兰氏阳性杆菌。它们是正常的胃肠道和泌尿生殖道微生物区系的一部分,很少被报道是感染的原因。乳杆菌被认为是非致病微生物,已被用作益生菌来预防抗生素相关性腹泻。有零星报告的与含有益生菌的乳杆菌有关的感染病例。本文讨论一例82岁女性在治疗艰难梭菌结肠炎的过程中使用含有乳酸菌的益生菌后出现肝脓肿和乳酸菌血症的病例。没有进行乳杆菌菌株鉴定,因此,共生微生物区系和益生菌产物都应该被认为是菌株的可能来源。乳酸菌可导致一些易感人群的菌血症和肝脓肿,随着含有乳酸菌的益生菌的使用增加,有必要更多地意识到这一潜在的副作用。
Lactobacilli are non-spore forming, lactic acid producing, gram-positive rods. They are a part of the normal gastrointestinal and genitourinary microbiota and have rarely been reported to be the cause of infections. Lactobacilli species are considered non-pathogenic organisms and have been used as probiotics to prevent antibiotic associated diarrhea. There are sporadic reported cases of infections related to lactobacilli containing probiotics. In this paper we discuss a case of an 82 year old female with liver abscess and bacteremia from lactobacillus after using probiotics containing lactobacilli in the course of her treatment of Clostridium difficile colitis. The Lactobacillus strain identification was not performed and therefore, both commensal microbiota and the probiotic product should be considered as possible sources of the strain. Lactobacilli can lead to bacteremia and liver abscesses in some susceptible persons and greater awareness of this potential side effect is warranted with the increasing use of probiotics containing lactobacilli.
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