Multimodal magnetic core-shell nanoparticles for effective stem-cell differentiation and imaging.
Multimodal magnetic core-shell nanoparticles for effective stem-cell differentiation and imaging.
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DOI：
10.1002/anie.201302245
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发表时间：
2013-06-10
影响因子：
16.6
通讯作者：
Lee, Ki-Bum
中科院分区：
文献类型：
--
作者：
Shah, Birju;Yin, Perry T.;Ghoshal, Shraboni;Lee, Ki-Bum
干细胞具有分化为特定功能的特殊细胞的能力，在再生医学领域具有巨大的潜力，其中这些基于干细胞的疗法可用于治疗包括糖尿病、心脏病和肝病在内的各种疾病。[1]然而，由于我们目前无法实现将遗传物质有效地输送到靶细胞，这是专门指导分化所必需的，严重阻碍了基于干细胞的疗法在临床上的实现。尤其是在干细胞再生医学方面，至关重要的是要实现：1)目标细胞的高效转基因；2)生物相容性，强调在不改变迁移和分化潜力的情况下保持高细胞活性；和iii)用于治疗的长期评估的非侵入性监测。[2]目前，使用病毒介导的传递导致干细胞的最高传递效率(80%-90%)。[3]然而，这种方法也具有一些限制其临床适用性的有害影响，包括潜在的细胞毒性、突变和免疫反应的诱导。[4]为此，已经投入了大量的努力来开发替代的非病毒传递方法。
Stem cells, owing to their ability to differentiate into specialized cells that can serve a particular function, have enormous potential in the field of regenerative medicine, wherein these stem cell-based therapies can be used to treat a wide range of diseases including diabetes, heart disease, and liver disease.[1] However, the realization of stem cell-based therapies in the clinic is severely hampered by our current inability to achieve the efficient delivery of genetic materials into target cells, which is required to specifically direct differentiation. In particular, with regard to stem cell-based regenerative medicine, it is vital to achieve: i) the highly efficient transfection of targeted cells; ii) biocompatibility, with an emphasis on maintaining a high cell viability without altering migratory and differentiation potential; and iii) non-invasive monitoring for the long-term evaluation of therapy.[2]Currently, the use of virus-mediated delivery results in the highest delivery efficiency (80–90%) for stem cells.[3] However, this method also has a number of harmful effects that limit its clinical applicability including potential cell toxicities, mutagenesis, and the induction of an immune response.[4] To this end, a significant amount of effort has been invested in the development of alternative non-viral delivery methods.[2c] In particular, recent studies have
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影响因子：
41.2
作者：
Seo, Won Seok;Lee, Jin Hyung;Dai, Hongjie
通讯作者：
Dai, Hongjie
影响因子：
5.2
作者：
Ma, Y;Ramezani, A;Thomson, JA
通讯作者：
Thomson, JA
影响因子：
17.1
作者：
Guo S;Huang Y;Jiang Q;Sun Y;Deng L;Liang Z;Du Q;Xing J;Zhao Y;Wang PC;Dong A;Liang XJ
通讯作者：
Liang XJ
多功能纳米颗粒作为耦合对比剂。
影响因子：
16.6
作者：
Jin, Yongdong;Jia, Congxian;Huang, Sheng-Wen;O'Donnell, Matthew;Gao, Xiaohu
通讯作者：
Gao, Xiaohu
影响因子：
17.1
作者：
Jenkins, Stuart I.;Pickard, Mark R.;Chari, Divya M.
通讯作者：
Chari, Divya M.