Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis.
Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis.
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DOI：
10.1186/s12903-022-02044-1
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发表时间：
2022-01-21
期刊：
影响因子：
2.9
通讯作者：
Troiano G
中科院分区：
文献类型：
--
作者：
Arena C;Caponio VCA;Zhurakivska K;Lo Russo L;Lo Muzio L;Troiano G
本系统综述和荟萃分析旨在研究阿仑膦酸钠联合牙周治疗第2步在减少探诊袋深度、改善临床附着水平和减少骨内和根间缺损的骨缺损深度方面的作用。本研究纳入了随访时间超过6个月的RCT。使用科克伦协作工具进行偏倚风险评估。此外，采用荟萃分析和试验序贯分析来汇总现有证据。七项研究符合纳入标准并被纳入系统性综述。局部应用阿仑膦酸钠在牙周治疗的第二步显着改善PD和CAL。局部应用阿仑膦酸钠可能会赋予一个有益的效果时，应用在牙周治疗的第二步，即使需要长期的研究来证实这些结果。考虑到宿主炎症反应在牙周炎治疗中的新作用以及双膦酸盐的抗吸收和骨刺激特性，一些研究集中在阿仑膦酸钠作为非手术牙周治疗的补充的作用。在线版本包含补充材料，可通过10.1186/s12903-022-02044-1获得。
This systematic review and meta-analysis aimed to investigate the role of alendronate combined with step 2 of periodontal therapy in reducing probing pocket depth, improving clinical attachment level, and reducing bone defect depth in intra-bony and inter-radicular defects. RCTs with more than 6 months follow-up were included in this study. Risk of bias assessment was performed using the Cochrane collaboration tool. In addition, meta-analysis and trial sequential analysis were used to aggregate the available evidence. Seven studies met the inclusion criteria and were included in the systematic review. Topical application of alendronate during second step of periodontal therapy significantly improved PD and CAL. Local application of alendronate may confer a beneficial effect when applied during step II of periodontal therapy even if long term studies are needed to confirm these results. Considering the emerging role of host-inflammatory response in treatment of periodontitis and the antiresorptive and osteostimulative properties of bisphosphonates, several studies are focusing on the role of alendronate as an addition to non-surgical periodontal therapy. The online version contains supplementary material available at 10.1186/s12903-022-02044-1.
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影响因子：
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