Comparison of radial 4D Flow-MRI with perivascular ultrasound to quantify blood flow in the abdomen and introduction of a porcine model of pre-hepatic portal hypertension.
Comparison of radial 4D Flow-MRI with perivascular ultrasound to quantify blood flow in the abdomen and introduction of a porcine model of pre-hepatic portal hypertension.
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DOI：
10.1007/s00330-017-4862-4
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发表时间：
2017-12
影响因子：
5.9
通讯作者：
Reeder SB
中科院分区：
文献类型：
--
作者：
Frydrychowicz A;Roldan-Alzate A;Winslow E;Consigny D;Campo CA;Motosugi U;Johnson KM;Wieben O;Reeder SB
本研究的目的是比较径向时间分辨相位对比磁共振成像（4D Flow-MRI）与血管周围超声（pvUS），并探讨急性肝前性门脉高压症（PHTN）的猪模型。对13头体重约60 kg的猪进行腹部4D Flow-MRI和门静脉和脾静脉、肝动脉和双肾动脉的pvUS。在6只猪中，在部分门静脉（PV）结扎后重复测量。进行了阅片者间和阅片者内比较和统计分析，包括Bland-Altman（BA）比较、配对Student t检验和线性回归。PVUS和4D Flow-MRI测量结果一致;部分肺静脉结扎前的血流在PVUS中为322 ± 30 ml/min，在MRI中为297 ± 27 ml/min（p = 0.294），平均BA差异为25 ml/min [−322; 372]。读片者间和读片者内的结果差异很小，显示出良好的相关性（R2分别= 0.98和0.99），并导致BA差异分别为-5 ml/min [-161; 150]和-2 ml/min [-28; 25]。肺静脉结扎后，肺静脉血流从356 ± 50 ml/min降至298 ± 61 ml/min（p = 0.02），肝动脉血流从277 ± 36 ml/min增至331 ± 65 ml/min（p = n.s.）。径向4D Flow-MRI与血管周围超声的成功体内比较显示腹部血流具有良好的一致性，尽管结果具有相当大的范围。成功地引入了肝前PHTN模型，并监测了急性反应。
Objectives of this study were to compare radial time-resolved phase contrast magnetic resonance imaging (4D Flow-MRI) with perivascular ultrasound (pvUS) and to explore a porcine model of acute pre-hepatic portal hypertension (PHTN). Abdominal 4D Flow-MRI and pvUS in portal and splenic vein, hepatic and both renal arteries were performed in 13 pigs of approximately 60 kg. In six pigs, measurements were repeated after partial portal vein (PV) ligature. Inter-and intra-reader comparisons and statistical analysis including Bland–Altman (BA) comparison, paired Student’s t tests and linear regression were performed. PvUS and 4D Flow-MRI measurements agreed well; flow before partial PV ligature was 322 ± 30 ml/min in pvUS and 297 ± 27 ml/min in MRI (p = 0.294), and average BA difference was 25 ml/min [−322; 372]. Inter- and intra-reader results differed very little, revealed excellent correlation (R2 = 0.98 and 0.99, respectively) and resulted in BA differences of −5 ml/min [−161; 150] and −2 ml/min [−28; 25], respectively. After PV ligature, PV flow decreased from 356 ± 50 to 298 ± 61 ml/min (p = 0.02), and hepatic arterial flow increased from 277 ± 36 to 331 ± 65 ml/min (p = n.s.). The successful in vivo comparison of radial 4D Flow-MRI to perivascular ultrasound revealed good agreement of abdominal blood flow although with considerable spread of results. A model of pre-hepatic PHTN was successfully introduced and acute responses monitored.
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影响因子：
3.1
作者：
Ganter, Christoph C.;Buser, Christof;Jakob, Stephan M.
通讯作者：
Jakob, Stephan M.
影响因子：
6.7
作者：
Ley, Sebastian;Unterhinninghofen, Roland;Szabo, Gabor
通讯作者：
Szabo, Gabor
影响因子：
3.3
作者：
Jung, Bernd;Honal, Matthias;Markl, Michael
通讯作者：
Markl, Michael
影响因子：
4.4
作者：
Frydrychowicz, A.;Landgraf, B. R.;Niespodzany, E.;Verma, R. W.;Roldan-Alzate, A.;Johnson, K. M.;Wieben, O.;Reeder, S. B.
通讯作者：
Reeder, S. B.
影响因子：
6.7
作者：
Frydrychowicz A;Wieben O;Niespodzany E;Reeder SB;Johnson KM;François CJ
通讯作者：
François CJ