Improved measurement of pressure gradients in aortic coarctation by magnetic resonance imaging.
Improved measurement of pressure gradients in aortic coarctation by magnetic resonance imaging.
复制标题
通过磁共振成像改进主动脉缩窄压力梯度的测量。
DOI：
10.1016/s0735-1097(96)00395-6
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发表时间：
1996
影响因子：
24
通讯作者：
Pettigrew,RI
中科院分区：
文献类型：
--
作者：
Oshinski,JN;Parks,WJ;Markou,CP;Bergman,HL;Larson,BE;Ku,DN;MukundanJr,S;Pettigrew,RI
研究目的本研究评价磁共振成像和磁共振相速度图能否准确估计主动脉缩窄的狭窄程度和压力梯度。背景临床治疗主动脉缩窄需要确定病变的位置和严重程度，并量化狭窄区域的压力梯度。方法使用一系列准确的主动脉缩窄模型，实验室部分发现损失系数(K)是狭窄严重程度的函数，在简化的伯努利方程ΔP=KV2中，K通常被认为是4.0.50%狭窄时的损失系数为2.8，90%狭窄时损失系数为4.9。结果应用新的严重程度相关损失系数计算出的压力梯度与通常使用的4.0值相比偏离了1~17 mm Hg。磁共振压力梯度估计值与多普勒超声估计值(32例患者中的22例)和导管压力测量结果(32例患者中的6例)的比较支持这样的结论，即基于严重程度的损失系数提供了更好的压力梯度估计。结论本研究表明，通过确定狭窄的位置和严重程度以及准确地估计压力梯度，MRI可以作为一种完整的诊断工具用于准确评估主动脉缩窄。
ObjectivesThis study evaluated whether magnetic resonance imaging (MRI) and magnetic resonance (MR) phase velocity mapping could provide accurate estimates of stenosis severity and pressure gradients in aortic coarctation.BackgroundClinical management of aortic coarctation requires determination of lesion location and severity and quantification of the pressure gradient across the constricted area.MethodsUsing a series of anatomically accurate models of aortic coarctation, the laboratory portion of this study found that the loss coefficient (K), commonly taken to be 4.0 in the simplified Bernoulli equation ΔP = KV2, was a function of stenosis severity. The values of the loss coefficient ranged from 2.8 for a 50% stenosis to 4.9 for a 90% stenosis. Magnetic resonance imaging and MR phase velocity mapping were then used to determine coarctation severity and pressure gradient in 32 patients.ResultsApplication of the new severity-dependent loss coefficients found that pressure gradients deviated from 1 to 17 mm Hg compared with calculations made with the commonly used value of 4.0. Comparison of MR estimates of pressure gradient with Doppler ultrasound estimates (in 22 of 32 patients) and with catheter pressure measurements (in 6 of 32 patients) supports the conclusion that the severity-based loss coefficient provides improved estimates of pressure gradients.ConclusionsThis study suggests that MRI could be used as a complete diagnostic tool for accurate evaluation of aortic coarctation, by determining stenosis location and severity and by accurately estimating pressure gradients.
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影响因子：
4.8
作者：
SONDERGAARD, L;HILDEBRANDT, P;HENRIKSEN, O
通讯作者：
HENRIKSEN, O
主髂疾病：二维流入磁共振血管造影与脂质抑制
影响因子：
4.4
作者：
S. Mulligan;M. Doyle;T. Matsuda;D. B. Koslin;P. Kenney;R. Barton;G. Pohost
通讯作者：
G. Pohost
外周动脉狭窄模型压力梯度多普勒测量的验证。
影响因子：
4.3
作者：
G. Weber;A. Strauss;H. Rieger;A. Scheffler;J. Eisenhoffer
通讯作者：
J. Eisenhoffer
加速度对 MR 相速度测量精度的影响
影响因子：
4.4
作者：
J. Oshinski;D. Ku;D. Bohning;R. Pettigrew
通讯作者：
R. Pettigrew
影响因子：
--
作者：
M. Campbell
通讯作者：
M. Campbell