The therapeutic potential of CRTH2/DP2 beyond allergy and asthma.
The therapeutic potential of CRTH2/DP2 beyond allergy and asthma.
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DOI：
10.1016/j.prostaglandins.2017.08.006
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发表时间：
2017-11
影响因子：
2.9
通讯作者：
Heinemann A
中科院分区：
文献类型：
--
作者：
Jandl K;Heinemann A
前列腺素(PG)D2长期以来一直是研究的重点，但其生物学效应及其在人类疾病中的作用尚不完全清楚。2001年，当发现了第二种主要的PGD2受体，称为Th2细胞上表达的趋化受体同系物(CRTH2；替代名称DP2)时，各种研究开始更多地揭示前列腺素的复杂且往往有争议的作用。CRTH2具有多种免疫调节作用，如在体内和体外观察到诱导白细胞迁移、激活和释放细胞因子等，因此CRTH2已成为治疗变态反应性疾病的有前途的靶点。然而，随着对CRTH2的研究越来越多，人们也清楚地看到，它的生物学作用比最初预期的要多样化得多。在这篇综述中，我们旨在总结PGD2，尤其是CRTH2在中枢神经系统、肾、肠、肺、头发和皮肤、骨和软骨以及癌症中可能发挥的作用。根据目前的数据，我们认为阻断CRTH2可能是一种潜在的治疗方法，可以治疗经典变态反应性疾病和哮喘以外的许多疾病。
Prostaglandin (PG) D2 has been in the focus of research for quite a long time, but its biological effects and its roles in human disease are still not fully characterized. When in 2001 a second major PGD2 receptor termed chemoattractant receptor homologue expressed on Th2 cells (CRTH2; alternative name DP2) was discovered, diverse investigations started to shed more light on the complex and often controversial actions of the prostaglandin. With various immunomodulating effects, such as induction of migration, activation, and cytokine release of leukocytes observed both in vivo and in vitro, CRTH2 has emerged as a promising target for the treatment of allergic diseases. However, with more and more research being performed on CRTH2, it has also become clear that its biological actions are far more diverse than expected at the beginning. In this review, we aim to summarize the roles that PGD2 – and CRTH2 in particular – might play in diseases of the central nervous system, kidney, intestine, lung, hair and skin, bone and cartilage, and in cancer. Based on current data we propose that blocking CRTH2 might be a potential therapeutic approach to numerous conditions beyond classical allergic diseases and asthma.
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
14.2
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DOI：
10.1084/jem.193.2.255
发表时间：
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期刊：
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