The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population.
The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population.
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DOI：
10.1371/journal.pone.0057012
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Hu M;Zhao L;Hu S;Yang J
新的证据表明microRNAs（miRNAs）作为肿瘤抑制因子或癌基因参与了人类肿瘤的发生。miRNAs中的单核苷酸多态性（single nucleotide polymorphism，SNP）可能影响成熟miRNAs的功能，进而影响肿瘤的发生过程。有研究表明，miR-146 a中的两个常见SNP rs 2910164和miR-499中的rs3746444与肝细胞癌（HCC）的易感性相关。然而，发表的结果是不一致的和不确定的。为了获得这些多态性与HCC风险之间的关联的更精确的效果，我们进行了这项荟萃分析。我们在PubMed、ScienceDirect、科克伦对照试验中心和中国国家知识基础设施数据库中检索了关于SNPs rs 2910164和/或rs3746444与HCC易感性关系的病例对照研究，时间截止到2012年9月10日。共有6项研究确定了2071例病例和2350例对照的miR-146 a rs 2910164多态性，667例病例和1006例对照的miR-499 rs3746444多态性。结果发现，无论是等位基因频率还是基因型分布的两个多态性与肝癌的风险在所有的遗传模型。同样，亚洲人群的亚组分析显示，两个SNP与HCC易感性之间没有关联。这项荟萃分析表明，miR-146 a rs 2910164和miR-499 rs3746444多态性可能与HCC的风险无关，尤其是在亚洲人群中。然而，需要设计良好的研究，更大的样本量和更详细的数据来证实这些结论。
Emerging evidence has shown that microRNAs (miRNAs) participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) located in the miRNAs may influence the function of mature miRNAs and then affect the processing of carcinogenesis. It has been suggested that two common SNPs rs2910164 in miR-146a and rs3746444 in miR-499 are associated with susceptibility to hepatocellular carcinoma (HCC). However, published results are inconsistent and inconclusive. To acquire a more precise effect of the association between these polymorphisms and HCC risk, we performed this meta-analysis. We have conducted a search of case-control studies on the associations of SNPs rs2910164 and/or rs3746444 with susceptibility to HCC in PubMed, ScienceDirect, Cochrane Central Register of Controlled Trials, and Chinese National Knowledge Infrastructure databases for the period up to Sep 10th, 2012. A total of 6 studies were identified with 2071 cases and 2350 controls for miR-146a rs2910164 polymorphism, 667 cases and 1006 controls for miR-499 rs3746444 polymorphism. It was found that neither allele frequency nor genotype distribution of the two polymorphisms was associated with risk of HCC in all genetic models. Similarly, subgroup analysis in Asian population showed no associations between the two SNPs and the susceptibility to HCC. This meta-analysis suggests that miR-146a rs2910164 and miR-499 rs3746444 polymorphisms may not be associated with the risk of HCC, especially for Asian population. However, well-designed studies with larger sample size and more detailed data are needed to confirm these conclusions.
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影响因子：
11.2
作者：
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