Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines.
Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines.
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DOI：
10.1093/infdis/jiy515
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发表时间：
2019-01-07
期刊：
影响因子：
--
通讯作者：
Oshitani H
中科院分区：
文献类型：
--
作者：
Furuse Y;Tamaki R;Okamoto M;Saito-Obata M;Suzuki A;Saito M;Imamura T;Khandaker I;Dapat I;Ueno F;Alday PP;Tan AG;Inobaya MT;Segubre-Mercado E;Tallo V;Lupisan S;Oshitani H
一项关于菲律宾儿童急性呼吸道感染的前瞻性队列研究发现，在感染了腺病毒、甲型流感病毒、4型副流感病毒和C类鼻病毒后，继发呼吸道感染的风险显著增加。急性呼吸道感染(ARI)是公共卫生中非常令人关注的问题。目前尚不清楚病毒感染是否会影响宿主对后续ARI的易感性。2014年至2016年，一项关于5岁以下儿童ARI的前瞻性队列研究在菲律宾进行。每天记录呼吸道症状，并在家庭和卫生设施收集鼻咽拭子。对样本进行了呼吸道病毒检测。然后，我们确定病毒病原学是否与目前ARI的严重程度相关，以及先前的病毒感染是否与随后的ARI相关。共有3,851名儿童和16337名ARI儿童分别被登记和记录。样本采集自24%的急性呼吸窘迫综合征发作；医疗机构的采集率为95%。肠道病毒D68、鼻病毒C和呼吸道合胞病毒与严重急性呼吸窘迫综合征显著相关。在感染了腺病毒、甲型流感病毒、4型副流感病毒和C型鼻病毒后，继发性ARI的风险显著增加。这项研究表明，病毒病原学在目前ARI的严重程度中起着重要作用，并且病毒感染影响宿主对继发性ARI的易感性。
A prospective cohort study on acute respiratory infections of children in the Philippines found that the risk for subsequent respiratory infections was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host’s susceptibility to subsequent ARIs. A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs. A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C. This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host’s susceptibility to subsequent ARIs.
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影响因子：
3.7
作者：
Kosai H;Tamaki R;Saito M;Tohma K;Alday PP;Tan AG;Inobaya MT;Suzuki A;Kamigaki T;Lupisan S;Tallo V;Oshitani H
通讯作者：
Oshitani H
流感在呼吸细菌疾病的严重程度和传播中的作用。
DOI：
10.1016/s2213-2600(14)70131-6
发表时间：
2014-09
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Mina MJ;Klugman KP
通讯作者：
Klugman KP
影响因子：
3.1
作者：
Bellau-Pujol S;Vabret A;Legrand L;Dina J;Gouarin S;Petitjean-Lecherbonnier J;Pozzetto B;Ginevra C;Freymuth F
通讯作者：
Freymuth F
影响因子：
4.2
作者：
De Lastours, V.;Malosh, R.;Foxman, B.
通讯作者：
Foxman, B.
影响因子：
3.8
作者：
Douros, Konstantinos;Kotzia, Doxa;Priftis, Kostas N.
通讯作者：
Priftis, Kostas N.