The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.

The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.
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杏仁核和中缝背核在调节不可避免的休克的行为后果中的作用。

DOI:
10.1037//0735-7044.107.2.377
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发表时间:
1993
影响因子:
1.9
通讯作者:
Watkins,LR
Watkins,LR
中科院分区:
医学4区
文献类型:
--
作者:
Maier,SF;Grahn,RE;Kalman,BA;Sutton,LC;Wiertelak,EP;Watkins,LR

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有人认为,暴露在不可避免的电击中会产生后来的行为变化,比如糟糕的穿梭箱逃生学习,因为它会导致强烈恐惧的条件反射,这种恐惧后来转移到穿梭箱测试情境中,干扰了逃生。在暴露于不可避免的电击24小时后,对Sprague-Dawley大鼠进行了恐惧和逃跑的测量。杏仁核基底外侧区和中央核的病变消除了不可避免的电击后转移到穿梭盒的恐惧,以及穿梭盒电击在穿梭盒中形成的恐惧。然而,杏仁核损伤并没有减少不可避免的电击造成的学习缺陷。相反,中缝背核损伤并没有减少不可避免的电击后转移到穿梭盒的恐惧,但消除了穿梭盒中恐惧条件反射的增强以及逃避赤字。这些结果对恐惧和焦虑在介导不可避免的冲击效应中的作用的含义进行了讨论。(PsycINFO数据库记录(c) 2016 APA,版权所有)
It has been argued that exposure to inescapable shock produces later behavioral changes such as poor shuttle box escape learning because it leads to the conditioning of intense fear, which later transfers to the shuttle box test situation and interferes with escape. Both fear, as assessed by freezing, and escape were measured in Sprague-Dawley rats 24 hrs after exposure to inescapable shock. Lesions of the basolateral region and central nucleus of the amygdala eliminated the fear that transfers to the shuttle box after inescapable shock, as well as the fear conditioned in the shuttle box by the shuttle box shocks. However, the amygdala lesions did not reduce the learning deficit produced by inescapable shock. In contrast, dorsal raphe nucleus lesions did not reduce the fear that transfers to the shuttle box after inescapable shock, but eliminated the enhanced fear conditioning in the shuttle box as well as the escape deficit. The implications of these results for the role of fear and anxiety in mediating inescapable shock effects are discussed.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
DOI: --
发表时间: 1985
影响因子: 7.3
作者:
S. Hindley;A. Hobbs;I. Paterson;M. Roberts
通讯作者: M. Roberts
DOI: --
发表时间: 1980
期刊: Brain Research
影响因子: 2.9
作者:
R. Kiser;Cora A. Brown;M. Sanghera;D. German
通讯作者: D. German
不可避免的冲击后的逃避缺陷:环境气味的作用。
DOI: --
发表时间: 1984
期刊:
影响因子: --
作者:
T. Minor;V. Lolordo
通讯作者: V. Lolordo
DOI: 10.1016/0006-8993(86)90020-x
发表时间: 1986-09-24
期刊: BRAIN RESEARCH
影响因子: 2.9
作者:
IWATA, J;LEDOUX, JE;REIS, DJ
通讯作者: REIS, DJ
精神病学动物模型,II
DOI: --
发表时间: 1991
期刊:
影响因子: --
作者:
A. Boulton;G. Baker;M. Martin
通讯作者: M. Martin