TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea.
TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea.
复制标题
DOI：
10.1093/nar/gkq908
复制
发表时间：
2011-01
影响因子：
14.9
通讯作者：
Deng Z
中科院分区：
文献类型：
--
作者：
Shao Y;Harrison EM;Bi D;Tai C;He X;Ou HY;Rajakumar K;Deng Z
TADB（http：//bioinfo-mml.sjtu.edu.cn/TADB/）是一个综合数据库，提供有关2型毒素-抗毒素（TA）基因座的全面信息，这些基因座丰富地分布在细菌和古细菌基因组中。两个基因和更少的三个基因的2型TA基因座编码同源的合作伙伴，已被假设或证明发挥关键作用的压力反应，细菌生理和稳定的水平获得的遗传因素。TADB提供了预测和实验支持的2型TA基因座相关数据的独特汇编，目前包含在1240个原核基因组中鉴定的10753个2型TA基因对，以及超过240个直接相关科学出版物的详细信息。广泛的相似性搜索，序列比对，基因组背景浏览器和系统发育工具都可以通过TADB轻松访问。我们建议，TADB将促进细菌和古菌2型TA空间的高效，多学科和创新的探索，更好地定义目前公认的TA相关现象，甚至可能导致尚未设想的前沿。TADB数据库被设想为第2类TA相关研究的一站式商店，将定期维护，更新和改进，以确保其对研究界的持续最大效用。
TADB (http://bioinfo-mml.sjtu.edu.cn/TADB/) is an integrated database that provides comprehensive information about Type 2 toxin–antitoxin (TA) loci, genetic features that are richly distributed throughout bacterial and archaeal genomes. Two-gene and much less frequently three-gene Type 2 TA loci code for cognate partners that have been hypothesized or demonstrated to play key roles in stress response, bacterial physiology and stabilization of horizontally acquired genetic elements. TADB offers a unique compilation of both predicted and experimentally supported Type 2 TA loci-relevant data and currently contains 10 753 Type 2 TA gene pairs identified within 1240 prokaryotic genomes, and details of over 240 directly relevant scientific publications. A broad range of similarity search, sequence alignment, genome context browser and phylogenetic tools are readily accessible via TADB. We propose that TADB will facilitate efficient, multi-disciplinary and innovative exploration of the bacteria and archaea Type 2 TA space, better defining presently recognized TA-related phenomena and potentially even leading to yet-to-be envisaged frontiers. The TADB database, envisaged as a one-stop shop for Type 2 TA-related research, will be maintained, updated and improved regularly to ensure its ongoing maximum utility to the research community.
登录
查看更多内容
影响因子：
4.5
作者：
Wozniak RA;Waldor MK
通讯作者：
Waldor MK
影响因子：
3.2
作者：
Jorgensen, Mikkel G.;Pandey, Deo P.;Gerdes, Kenn
通讯作者：
Gerdes, Kenn
影响因子：
5.8
作者：
Waterhouse, Andrew M.;Procter, James B.;Barton, Geoffrey J.
通讯作者：
Barton, Geoffrey J.
影响因子：
4.4
作者：
Suzuki, Y;Kelly, SD;Banfield, JF
通讯作者：
Banfield, JF
影响因子：
5.5
作者：
Makarova KS;Wolf YI;Koonin EV
通讯作者：
Koonin EV