Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.
Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.
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DOI：
10.1038/s41380-023-02039-6
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发表时间：
2023-06
影响因子：
11
通讯作者：
Cloninger, C. Robert
中科院分区：
文献类型：
--
作者：
Zwir, Igor;Arnedo, Javier;Mesa, Alberto;del Val, Coral;de Erausquin, Gabriel A.;Cloninger, C. Robert
人类大脑的静息状态功能连接(RsFC)提供了对个体感知、认知、情感和社会功能差异的稳定的、类似于特征的测量。前额叶皮质的rsFC被假设为调节一个人的理性自治，这也是通过人格来衡量的，所以我们测试了它的连接网络是否解释了精神病和相关人格配置的易感性。年轻的成年人被招募为门诊患者或对照组，来自精神病院周围的相同社区。健康对照组(n = 30例)和临床稳定的双相情感障碍(n = 35例)或精神分裂症(n = 2 7例)患者通过结构化访谈确诊，然后用人类连接组计划的标准化方案进行评估。数据驱动的聚类法确定了五组患者，他们的rsFC模式不同，与诊断无关。这些群体通过rsFC网络来区分，rsFC网络调节精神病的特定生物心理社会方面：感觉超敏、负情绪平衡、注意力控制受损、孤独感和社会不信任。RsFc组的差异通过不用于识别受试者的白质微观结构、个性和临床特征的独立测量来验证。我们证实，每个连接组是由6个前额叶网络和8个其他自动共激活的网络之间的不同协作交互组成的。这些群体成员的气质和性格特征强烈地解释了群体间rsFC的差异，表明rsFC的结构是人格组织的内在表征。这些表征包括自我调节能力较弱的恐惧、非理性欲望和不信任的情绪驱动，这些都容易导致精神病态。然而，不同诊断的稳定的门诊患者(双相或精神分裂症)在rsFC和人格特征上有很高的相似性。这支持了一种素质-压力模型，在该模型中，不同的复杂适应系统调节易感性(尽管确诊但在稳定的门诊患者中相似)和应激诱导的临床功能障碍(因诊断而不同)。
The human brain’s resting-state functional connectivity (rsFC) provides stable trait-like measures of differences in the perceptual, cognitive, emotional, and social functioning of individuals. The rsFC of the prefrontal cortex is hypothesized to mediate a person’s rational self-government, as is also measured by personality, so we tested whether its connectivity networks account for vulnerability to psychosis and related personality configurations. Young adults were recruited as outpatients or controls from the same communities around psychiatric clinics. Healthy controls (n = 30) and clinically stable outpatients with bipolar disorder (n = 35) or schizophrenia (n = 27) were diagnosed by structured interviews, and then were assessed with standardized protocols of the Human Connectome Project. Data-driven clustering identified five groups of patients with distinct patterns of rsFC regardless of diagnosis. These groups were distinguished by rsFC networks that regulate specific biopsychosocial aspects of psychosis: sensory hypersensitivity, negative emotional balance, impaired attentional control, avolition, and social mistrust. The rsFc group differences were validated by independent measures of white matter microstructure, personality, and clinical features not used to identify the subjects. We confirmed that each connectivity group was organized by differential collaborative interactions among six prefrontal and eight other automatically-coactivated networks. The temperament and character traits of the members of these groups strongly accounted for the differences in rsFC between groups, indicating that configurations of rsFC are internal representations of personality organization. These representations involve weakly self-regulated emotional drives of fear, irrational desire, and mistrust, which predispose to psychopathology. However, stable outpatients with different diagnoses (bipolar or schizophrenic psychoses) were highly similar in rsFC and personality. This supports a diathesis-stress model in which different complex adaptive systems regulate predisposition (which is similar in stable outpatients despite diagnosis) and stress-induced clinical dysfunction (which differs by diagnosis).
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影响因子：
25.8
作者：
Chopra S;Francey SM;O'Donoghue B;Sabaroedin K;Arnatkeviciute A;Cropley V;Nelson B;Graham J;Baldwin L;Tahtalian S;Yuen HP;Allott K;Alvarez-Jimenez M;Harrigan S;Pantelis C;Wood SJ;McGorry P;Fornito A
通讯作者：
Fornito A
影响因子：
3.3
作者：
Acharya, Jyotibdha;Basu, Arindam;Wu, Xundong
通讯作者：
Wu, Xundong
DOI：
10.3109/00048670903270506
发表时间：
2009-01-01
影响因子：
4.6
作者：
Cloninger, C. Robert
通讯作者：
Cloninger, C. Robert
影响因子：
3.3
作者：
Cloninger, CR;Svrakic, NM;Svrakic, DM
通讯作者：
Svrakic, DM
影响因子：
6.6
作者：
Cloninger, C. Robert;Zohar, Ada H.
通讯作者：
Zohar, Ada H.