Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.
Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury.
复制标题
胚胎干细胞来源的细胞外囊泡促进肾损伤的恢复
DOI：
10.1186/s13287-021-02460-0
复制
发表时间：
2021-07-02
影响因子：
7.5
通讯作者：
Liu N
中科院分区：
文献类型：
--
作者：
Yu L;Liu S;Wang C;Zhang C;Wen Y;Zhang K;Chen S;Huang H;Liu Y;Wu L;Han Z;Chen X;Li Z;Liu N
BackgroundEmbryonic stem cell-derived extracellular vesicles (ESC-EVs) possess therapeutic potential for a variety of diseases and are considered as an alternative of ES cells. Acute kidney injury (AKI) is a common acute and severe disease in clinical practice, which seriously threatens human life and health. However, the roles and mechanisms of ESC-EVs on AKI remain unclear.MethodsIn this study, we evaluated the effects of ESC-EVs on physiological repair and pathological repair using murine ischemia-reperfusion injury-induced AKI model, the potential mechanisms of which were next investigated. EVs were isolated from ESCs and EVs derived from mouse fibroblasts as therapeutic controls. We then investigated whether ESC-EVs can restore the structure and function of the damaged kidney by promoting physiological repair and inhibiting the pathological repair process after AKI in vivo and in vitro.ResultsWe found that ESC-EVs significantly promoted the recovery of the structure and function of the damaged kidney. ESC-EVs increased the proliferation of renal tubular epithelial cells, facilitated renal angiogenesis, inhibited the progression of renal fibrosis, and rescued DNA damage caused by ischemia and reperfusion after AKI. Finally, we found that ESC-EVs play a therapeutic effect by activating Sox9+cells.ConclusionsESC-EVs significantly promote the physiological repair and inhibit the pathological repair after AKI, enabling restoration of the structure and function of the damaged kidney. This strategy might emerge as a novel therapeutic strategy for ESC clinical application.
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DOI：
10.1159/000313738
发表时间：
2010-01-01
期刊：
CARDIORENAL SYNDROMES IN CRITICAL CARE
影响因子：
--
作者：
Bonventre, Joseph V.
通讯作者：
Bonventre, Joseph V.
间充质基质细胞衍生的细胞外囊泡通过 miR-30 抑制线粒体裂变改善急性肾缺血再灌注损伤
影响因子：
4.3
作者：
Gu D;Zou X;Ju G;Zhang G;Bao E;Zhu Y
通讯作者：
Zhu Y
影响因子：
16
作者：
Crescitelli, Rossella;Lasser, Cecilia;Lotvall, Jan
通讯作者：
Lotvall, Jan
影响因子：
23.9
作者：
Humphreys, Benjamin D.;Valerius, M. Todd;Bonventre, Joseph V.
通讯作者：
Bonventre, Joseph V.
影响因子：
9.8
作者：
Huang, Jianhua;Inoue, Makoto;Hamada, Hirofumi
通讯作者：
Hamada, Hirofumi