Meta-Analysis of the Association of Trp64Arg Polymorphism ofβ3-Adrenergic Receptor Gene with Body Mass Index1
Meta-Analysis of the Association of Trp64Arg Polymorphism ofβ3-Adrenergic Receptor Gene with Body Mass Index1
复制标题
β3-肾上腺素受体基因Trp64Arg多态性与体重指数关联性的Meta分析1
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
T. Ogihara
中科院分区：
文献类型：
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作者：
T. Fujisawa;H. Ikegami;Y. Kawaguchi;T. Ogihara
据报道，β3-肾上腺素能受体基因（Trp 64 Arg）中的一种可能致病的多态性与一些人群中的体重增加、胰岛素抵抗的临床特征和2型糖尿病的早期发展相关。然而，这些发现在研究中并不一致，使得这种遗传标记与临床特征相关的假设存在争议。为了评估基因型对身体质量指数（BMI）的影响，我们对文献数据进行了荟萃分析，采用ANOVA扩展进行连续测量。在包含Trp 64 Arg变异受试者（n = 2447）和非Trp 64 Arg变异受试者（n = 6789）的共48个亚组中，BMI的汇总加权平均差异为0.30（95%置信区间，0.13-0.47）kg/m2，表明变异携带者的BMI高于正常纯合子受试者（平均高0.30 kg/m2）。在这种情况下，没有显著的证据反对效果的同质性（P = 0.36）。
A possible pathogenic polymorphism in the β3-adrenergic receptor gene (Trp64Arg) has been reported to be associated with increased body weight, clinical features of insulin resistance, and early development of type 2 diabetes mellitus in several populations. However, such findings have not been consistent among studies, making the hypothesis that this genetic marker is associated with clinical features controversial. To assess the effect of the genotypes on body mass index (BMI), we performed a meta-analysis of the data from the literature using an extension of ANOVA for continuous measures. In a total of 48 subgroups containing subjects with (n = 2447) and without (n = 6789) the Trp64Arg variant, the summary weighted mean difference in BMI was 0.30 (95% confidence interval, 0.13–0.47) kg/m2, indicating that variant carriers exhibited higher BMI (on the average, 0.30 kg/m2 higher) than normal homozygous subjects. In this case, there was no significant evidence against homogeneity of the effect (P = 0.36)....
影响因子：
158.5
作者：
WALSTON, J;SILVER, K;SHULDINER, AR
通讯作者：
SHULDINER, AR
影响因子：
9.8
作者：
D. Carmelli;L. Cardon;R. Fabsitz
通讯作者：
D. Carmelli;L. Cardon;R. Fabsitz
β3-肾上腺素能受体基因座在有糖尿病兄弟姐妹的白人家庭成员肥胖和非胰岛素依赖型糖尿病中的作用。
DOI：
10.1210/jcem.81.12.8954053
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
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作者：
Elbein,SC;Hoffman,M;Barrett,K;Wegner,K;Miles,C;Bachman,K;Berkowitz,D;Shuldiner,AR;Leppert,MF;Hasstedt,S
通讯作者：
Hasstedt,S