Robustness of STDP to spike timing jitter.
Robustness of STDP to spike timing jitter.
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DOI：
10.1038/s41598-018-26436-y
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发表时间：
2018-05-25
影响因子：
4.6
通讯作者：
Venance L
中科院分区：
文献类型：
--
作者：
Cui Y;Prokin I;Mendes A;Berry H;Venance L
在赫布可塑性中，神经回路根据模式化的放电来调整它们的突触权重。尖峰时间依赖性可塑性（STDP）是一种突触赫布学习规则，依赖于突触前和突触后神经元成对活动的顺序和时间。传统上，在离体实验中，STDP是用确定性（恒定）尖峰时间和连续配对之间的时间间隔进行评估的，因此表现出不同于生物变异性的规律性。因此，STDP出现从嘈杂的输入发生在体内一样的射击仍然没有解决。在这里，我们使用了噪声STDP配对，其中配对之间的尖峰定时和/或间隔是抖动的。我们探讨了电生理学和数学建模，抖动的影响，三种形式的STDP在皮质纹状体突触：NMDAR-LTP，endocannabinoid-LTD和endocannabinoid-LTP。我们发现，NMDAR-LTP是非常脆弱的抖动，而内源性大麻素的可塑性出现更大的阻力。当配对的频率或数量增加时，NMDAR-LTP变得更加稳健，并且尽管有强烈的抖动也可以表达。我们的研究结果确定内源性大麻素可塑性作为一个强大的STDP形式，而NMDAR-LTP抖动的敏感性随活动频率而变化。这为在学习和记忆的不同阶段发挥作用的机制提供了新的见解，并在体内类似活动中出现了赫布可塑性。
In Hebbian plasticity, neural circuits adjust their synaptic weights depending on patterned firing. Spike-timing-dependent plasticity (STDP), a synaptic Hebbian learning rule, relies on the order and timing of the paired activities in pre- and postsynaptic neurons. Classically, in ex vivo experiments, STDP is assessed with deterministic (constant) spike timings and time intervals between successive pairings, thus exhibiting a regularity that differs from biological variability. Hence, STDP emergence from noisy inputs as occurring in in vivo-like firing remains unresolved. Here, we used noisy STDP pairings where the spike timing and/or interval between pairings were jittered. We explored with electrophysiology and mathematical modeling, the impact of jitter on three forms of STDP at corticostriatal synapses: NMDAR-LTP, endocannabinoid-LTD and endocannabinoid-LTP. We found that NMDAR-LTP was highly fragile to jitter, whereas endocannabinoid-plasticity appeared more resistant. When the frequency or number of pairings was increased, NMDAR-LTP became more robust and could be expressed despite strong jittering. Our results identify endocannabinoid-plasticity as a robust form of STDP, whereas the sensitivity to jitter of NMDAR-LTP varies with activity frequency. This provides new insights into the mechanisms at play during the different phases of learning and memory and the emergence of Hebbian plasticity in in vivo-like activity.
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DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
4.3
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影响因子：
3.5
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影响因子：
25
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通讯作者：
Gerstner, Wulfram
影响因子：
2.5
作者：
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通讯作者：
Dan, Y