ATP-Dependent Infra-Slow (<0.1 Hz) Oscillations in Thalamic Networks
ATP-Dependent Infra-Slow (<0.1 Hz) Oscillations in Thalamic Networks
复制标题
丘脑网络中 ATP 依赖性次慢 (<0.1 Hz) 振荡
作者：
Magor L. Lőrincz;Freya Geall;Ying Bao;V. Crunelli;S. Hughes
越来越多的人类和动物EEG和静息状态fMRI研究表明，<0.1 Hz的脑活动中的自发低频波动（超慢振荡，ISO）代表了脑功能的基本组成部分，已知与更快的神经元整体振荡相关，调节行为表现并影响癫痫发作的易感性。虽然这些振荡通常被认为涉及丘脑，但其基本的细胞机制仍然知之甚少。在这里，我们表明，在背侧丘脑在体外的各种核可以表达一个强大的ISO在0.005-0.1赫兹，这是大大促进了激活代谢型谷氨酸受体（mGluRs）和/或乙酰胆碱受体（AchRs）。这种ISO是一种神经元群体现象，其调节更快的间隙连接（GJ）依赖性网络振荡，并且当AchR或mGluR被过度刺激时可以成为癫痫活动的基础。在单个丘脑皮质神经元中，ISO主要由节律性的、持久的超极化电位形成，该电位反映了A1受体的激活、ATP衍生的腺苷以及随后的Ba 2+敏感性K+通道的开放。我们认为，这ISO有可能非神经元的起源，并可能有助于塑造ISO在完整的大脑。
An increasing number of EEG and resting state fMRI studies in both humans and animals indicate that spontaneous low frequency fluctuations in cerebral activity at <0.1 Hz (infra-slow oscillations, ISOs) represent a fundamental component of brain functioning, being known to correlate with faster neuronal ensemble oscillations, regulate behavioural performance and influence seizure susceptibility. Although these oscillations have been commonly indicated to involve the thalamus their basic cellular mechanisms remain poorly understood. Here we show that various nuclei in the dorsal thalamus in vitro can express a robust ISO at ∼0.005–0.1 Hz that is greatly facilitated by activating metabotropic glutamate receptors (mGluRs) and/or Ach receptors (AchRs). This ISO is a neuronal population phenomenon which modulates faster gap junction (GJ)-dependent network oscillations, and can underlie epileptic activity when AchRs or mGluRs are stimulated excessively. In individual thalamocortical neurons the ISO is primarily shaped by rhythmic, long-lasting hyperpolarizing potentials which reflect the activation of A1 receptors, by ATP-derived adenosine, and subsequent opening of Ba2+-sensitive K+ channels. We argue that this ISO has a likely non-neuronal origin and may contribute to shaping ISOs in the intact brain.
影响因子：
2.5
作者：
MCCARLEY, RW;BENOIT, O;BARRIONUEVO, G
通讯作者：
BARRIONUEVO, G
影响因子：
3.7
作者：
Romei, Vincenzo;Brodbeck, Verena;Thut, Gregor
通讯作者：
Thut, Gregor
影响因子：
2.5
作者：
Zhang, Dongyang;Snyder, Abraham Z.;Raichle, Marcus E.
通讯作者：
Raichle, Marcus E.