Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
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寨卡病毒：自最近流行病开始以来，我们学到了什么？
DOI：
10.3389/fmicb.2017.01554
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发表时间：
2017
影响因子：
5.2
通讯作者：
Pimentel-Coelho PM
中科院分区：
文献类型：
--
作者：
Saiz JC;Martín-Acebes MA;Bueno-Marí R;Salomón OD;Villamil-Jiménez LC;Heukelbach J;Alencar CH;Armstrong PK;Ortiga-Carvalho TM;Mendez-Otero R;Rosado-de-Castro PH;Pimentel-Coelho PM
寨卡病毒是一种主要由伊蚊属蚊子传播的病毒性疾病。近年来，它在地理上有所扩大，从赤道亚洲和非洲的地方性蚊媒疾病转变为在世界几个地区造成大规模爆发的流行病。随着最近寨卡病毒（ZIKV）在美洲的爆发，该疾病已成为公共卫生机构和国际研究界关注的焦点，特别是由于与成人神经障碍的关联以及在妊娠期间暴露于ZIKV的母亲的胎儿和新生儿中发现的严重神经和眼科异常。在过去的三年里，已经发表了大量的研究，揭示了病毒的结构，它是如何传播的，以及它如何影响人类细胞。已经开发了许多不同的动物模型，其概括了ZIKV疾病的几个特征及其神经学后果。此外，几种候选疫苗目前正在积极进行临床前开发，其中三种已经进入I期临床试验。同样，许多不同的针对病毒和细胞成分的化合物正在体外和实验动物模型中进行测试。本综述旨在从多学科的角度讨论这一快速增长的文献的现状，并概述对寨卡病毒的公共卫生反应以及预防和治疗这种疾病的前景。
Zika is a viral disease transmitted mainly by mosquitoes of the genus Aedes. In recent years, it has expanded geographically, changing from an endemic mosquito-borne disease across equatorial Asia and Africa, to an epidemic disease causing large outbreaks in several areas of the world. With the recent Zika virus (ZIKV) outbreaks in the Americas, the disease has become a focus of attention of public health agencies and of the international research community, especially due to an association with neurological disorders in adults and to the severe neurological and ophthalmological abnormalities found in fetuses and newborns of mothers exposed to ZIKV during pregnancy. A large number of studies have been published in the last 3 years, revealing the structure of the virus, how it is transmitted and how it affects human cells. Many different animal models have been developed, which recapitulate several features of ZIKV disease and its neurological consequences. Moreover, several vaccine candidates are now in active preclinical development, and three of them have already entered phase I clinical trials. Likewise, many different compounds targeting viral and cellular components are being tested in in vitro and in experimental animal models. This review aims to discuss the current state of this rapidly growing literature from a multidisciplinary perspective, as well as to present an overview of the public health response to Zika and of the perspectives for the prevention and treatment of this disease.
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影响因子：
19
作者：
Amraoui, F.;Atyame-Nten, C.;Failloux, A. B.
通讯作者：
Failloux, A. B.
影响因子：
2.6
作者：
Beisel, Uli;Boete, Christophe
通讯作者：
Boete, Christophe
影响因子：
4.9
作者：
Bennett, Kelly Louise;Shija, Fortunate;Walton, Catherine
通讯作者：
Walton, Catherine
影响因子：
30.3
作者：
Barrows NJ;Campos RK;Powell ST;Prasanth KR;Schott-Lerner G;Soto-Acosta R;Galarza-Muñoz G;McGrath EL;Urrabaz-Garza R;Gao J;Wu P;Menon R;Saade G;Fernandez-Salas I;Rossi SL;Vasilakis N;Routh A;Bradrick SS;Garcia-Blanco MA
通讯作者：
Garcia-Blanco MA
DOI：
10.1126/science.aah6157
发表时间：
2016-09-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Abbink P;Larocca RA;De La Barrera RA;Bricault CA;Moseley ET;Boyd M;Kirilova M;Li Z;Ng'ang'a D;Nanayakkara O;Nityanandam R;Mercado NB;Borducchi EN;Agarwal A;Brinkman AL;Cabral C;Chandrashekar A;Giglio PB;Jetton D;Jimenez J;Lee BC;Mojta S;Molloy K;Shetty M;Neubauer GH;Stephenson KE;Peron JP;Zanotto PM;Misamore J;Finneyfrock B;Lewis MG;Alter G;Modjarrad K;Jarman RG;Eckels KH;Michael NL;Thomas SJ;Barouch DH
通讯作者：
Barouch DH