Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?
Selenoprotein S: a therapeutic target for diabetes and macroangiopathy?
复制标题
硒蛋白 S：糖尿病和大血管病的治疗靶点？
DOI：
10.1186/s12933-017-0585-8
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发表时间：
2017-08-10
影响因子：
9.3
通讯作者：
Du JL
中科院分区：
文献类型：
--
作者：
Yu SS;Du JL
炎症反应、氧化应激和内质网应激是糖尿病及其大血管并发症发生发展的重要病理生理基础。硒蛋白S（Selenoprotein S，SELENOS）参与了这些机制的调控，因此，其与糖尿病及大血管病变的关系逐渐受到国内外学者的关注。硒在不同的组织和器官中具有不同的生物学功能：它在胰腺和血管中发挥抗氧化保护作用并具有抗ER应激作用，同时它促进肝脏，脂肪组织和骨骼肌中胰岛素抵抗的发生和发展。此外，研究证实，某些SELENOS基因多态性可影响炎症反应，并与发生DM和大血管病变的风险密切相关。因此，全面了解SELENOS与炎症、氧化应激和ER应激之间的关系，可以更好地阐明和补充DM和大血管病变并发症的致病机制。此外，深入研究不同组织和器官中的SELENOS功能与DM和大血管病变的相关性，可能有助于制定预防和治疗DM和大血管并发症的新策略。在这里，我们总结了共识和争议的功能，目前可用的证据。
Inflammatory response, oxidative stress, and endoplasmic reticulum (ER) stress are important pathophysiological bases of the occurrence and development of diabetes mellitus (DM) and macroangiopathy complications. Selenoprotein S (SELENOS) is involved in the regulation of these mechanisms; therefore, its association with DM and macroangiopathy has gradually received attention from scholars worldwide. SELENOS has different biological functions in different tissues and organs: it exerts antioxidant protection and has anti-ER stress effects in the pancreas and blood vessels, while it promotes the occurrence and development of insulin resistance in the liver, adipose tissue, and skeletal muscle. In addition, studies have confirmed that some SELENOS gene polymorphisms can influence the inflammatory response and are closely associated with the risk for developing DM and macroangiopathy. Therefore, comprehensive understanding of the association between SELENOS and inflammation, oxidative stress, and ER stress may better elucidate and supplement the pathogenic mechanisms of DM and macroangiopathy complications. Furthermore, in-depth investigation of the association of SELENOS function in different tissues and organs with DM and macroangiopathy may facilitate the development of new strategies for the prevention and treatment of DM and macrovascular complications. Here, we summarize the consensus and controversy regarding functions of SELENOS on currently available evidence.
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DOI：
10.1016/j.bbrc.2007.03.018
发表时间：
2007-05-11
影响因子：
3.1
作者：
Gao, Yuan;Pagnon, Joanne;Collier, Greg R.
通讯作者：
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影响因子：
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影响因子：
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作者：
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