Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat
Effects of Taurine on Cerulein-Induced Acute Pancreatitis in the Rat
复制标题
牛磺酸对雨蛙素诱发的大鼠急性胰腺炎的影响
作者：
B. Ahn;Kwang Hee Kim;Goo Lee;H. Lee;Chang Duck Kim;Young Sik Kim;M. Son;W. Kim;T. Oh;J. Hyun
牛磺酸，或2-氨基乙磺酸，是一种细胞内氨基酸，并已被认为具有保护生物系统免受氧化组织损伤的功能。本研究的目的是确定牛磺酸对雨蛙肽诱导的大鼠急性胰腺炎的影响。通过以1小时间隔皮下注射雨蛙肽（40 µg/kg体重）诱导急性胰腺炎，而在第一次注射雨蛙肽后以分级剂量（分别为30、100或300 mg/kg）静脉注射牛磺酸。通过检测生化指标、组织髓过氧化物酶（MPO）和组织学改变来判断胰腺炎和肺损伤的严重程度。为了阐明牛磺酸的作用机制，检测了血清IL-1β和TNF-α水平以及组织中丙二醛（MDA）浓度。在蛙皮素诱导的急性水肿性胰腺炎中，牛磺酸治疗显著降低了高淀粉酶血症、组织MPO、胰腺水肿以及胰腺和肺损伤的程度。牛磺酸降低胰腺和肺组织中MDA的浓度，但不降低血清中细胞因子的浓度。结论：牛磺酸通过抑制氧自由基的产生，对雨蛙素诱导的急性胰腺炎和肺损伤具有保护作用。
Taurine, or 2-aminoethane sulfonic acid, is an intracellular amino acid and has been suggested to have a function in protecting biological systems from oxidative tissue damage. The aim of this study was to determine the effect of taurine against cerulein-induced acute pancreatitis in rats. Acute pancreatitis was induced by administering three subcutaneous injections of cerulein (40 µg/kg body weight) at 1-hour intervals, while taurine was administered intravenously at graded doses (30, 100, or 300 mg/kg, respectively) following the first cerulein injection. The severities of pancreatitis and lung injury were determined by measuring biochemical parameters, tissue myeloperoxidase (MPO), and histological changes. To clarify the mechanism of taurine, serum IL-1β and TNF-α levels and tissue concentrations of malondialdehyde (MDA) were evaluated. In cerulein-induced acute edematous pancreatitis, treatment with taurine significantly decreased hyperamylasemia, tissue MPO, pancreatic edema, and the extent of pancreatic and pulmonary injury. Taurine decreased MDA concentration in the pancreas and lung, but not the serum cytokine concentration. We would conclude that taurine has beneficial effects in cerulein-induced acute pancreatitis and lung injuries by preventing the production of oxygen free radicals.
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影响因子：
9
作者：
GUICE, KS;OLDHAM, KT;WARD, PA
通讯作者：
WARD, PA
牛磺酸在中性粒细胞对红细胞的体外氧化毒性中作用的证据。
DOI：
--
发表时间：
1985
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Thomas,EL;Grisham,MB;Melton,DF;Jefferson,MM
通讯作者：
Jefferson,MM
快速、广泛适用的筛选抑制缺血/再灌注中自由基形成的药物。
DOI：
10.1016/0160-5402(88)90057-5
发表时间：
1988
期刊：
Journal of pharmacological methods
影响因子：
--
作者：
Salaris,SC;Babbs,CF
通讯作者：
Babbs,CF
影响因子：
1.7
作者：
G. Schuller-Levis;Ronald E. Gordon;E. Park;K. Pendino;Debra L. Laskin
通讯作者：
G. Schuller-Levis;Ronald E. Gordon;E. Park;K. Pendino;Debra L. Laskin