Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial.
Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial.
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DOI：
10.1016/j.jpeds.2011.06.044
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发表时间：
2011-12
影响因子：
5.1
通讯作者：
O'Shea, Thomas Michael
中科院分区：
文献类型：
--
作者：
Moorman, Joseph Randall;Carlo, Waldemar A.;Kattwinkel, John;Schelonka, Robert L.;Porcelli, Peter J.;Navarrete, Christina T.;Bancalari, Eduardo;Aschner, Judy L.;Walker, Marshall Whit;Perez, Jose A.;Palmer, Charles;Stukenborg, George J.;Lake, Douglas E.;O'Shea, Thomas Michael
为检验心率特征（HRC）监测可改善新生儿预后这一假设。
在9个新生儿重症监护病房（NICU）对3003例极低出生体重婴儿进行两组平行、个体随机对照临床试验。一组显示HRC监测结果，另一组则隐藏该结果。主要结局是随机分组后120天内无呼吸机存活天数。次要结局包括死亡率、使用呼吸机天数、在NICU停留时间以及抗生素使用情况。
显示HRC监测结果的婴儿死亡率从10.2%降至8.1%（风险比 = 0.78，95%置信区间 = 0.61 - 0.99，P = 0.04，需监测的例数为48），并且无呼吸机存活天数有增加的趋势（120天中的95.9天，相比对照组的93.6天，P = 0.08）。死亡率获益集中在出生体重<1000g的婴儿（风险比 = 0.74，95%置信区间0.57 - 0.95，P = 0.02，需监测的例数为23）。其他结局无显著差异。
心率特征监测可降低极低出生体重婴儿的死亡率。
To test the hypothesis that heart rate characteristics (HRC) monitoring improves neonatal outcomes. Two-group, parallel, individually randomized controlled clinical trial of 3003 very low birth weight infants in 9 NICUs. In one group, HRC monitoring was displayed; in the other, it was masked. The primary outcome was number of days alive and ventilator-free in the 120 days after randomization. Secondary outcomes were mortality, number of ventilator days, NICU stay and antibiotic use. Mortality was reduced in infants whose HRC monitoring was displayed, from 10.2% to 8.1% (HR = 0.78, 95% CI = 0.61 to 0.99, P = 0.04, number needed to monitor 48), and there was a trend toward increased days alive and ventilator-free (95.9 of 120 days compared to 93.6 in controls, P = 0.08). Mortality benefit was concentrated in infants with birth weight <1000g (HR=0.74, 95% CI 0.57 to 0.95, P=0.02, number needed to monitor 23). There were no significant differences in the other outcomes. Heart rate characteristics monitoring can reduce mortality in very low birth weight infants.
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DOI：
10.1038/nri2566
发表时间：
2009-06
期刊：
Nature reviews. Immunology
影响因子：
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作者：
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